help button home button Am J Pathol Epitomics Buy 2 Antibodies Get 1 Free Special Offer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andrade, Z. A.
Right arrow Articles by Grimaud, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrade, Z. A.
Right arrow Articles by Grimaud, J. A.

American Journal of Pathology, Vol 124, 59-65, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Evolution of the schistosomal hepatic lesions in mice after curative chemotherapy

ZA Andrade and JA Grimaud

Mice with 64-day-old Schistosoma mansoni infection (+/- 27 worms, 8-12 pairs) were treated simultaneously with oxamniquine and hycanthone. The cure rate was 100%, and changes occurring thereafter in the liver were sequentially followed by means of histologic, ultrastructural, and immunofluorescence methods. Soon after treatment, hepatitic changes cleared up and periovular granulomas diminished in size. The predominant Type III collagen in granulomas was reduced, and the Type I showed no apparent increase, whereas Type IV did not seem to participate in the process. Collagen fibrils in periovular granulomas changed in texture from dense and more oriented to loose and disorganized. Fibroblasts, at first with marked signs of hyperfunction, became less so at a time when collagen fragments appeared within secondary lysosomes in macrophages and fibroblasts. Schistosomal ovular antigens remained sequestered inside the fibrotic granulomas up to the final, 39th day after treatment. Thus, specific treatment of schistosomiasis showed a beneficial effect upon the hepatic lesions from the very beginning and promoted changes in the periovular granulomas that indicated a rapid, although incomplete, resorption of fibrosis.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
G. F. COTA, R. A. PINTO-SILVA, C. M. F. ANTUNES, and J. R. LAMBERTUCCI
ULTRASOUND AND CLINICAL INVESTIGATION OF HEPATOSPLENIC SCHISTOSOMIASIS: EVALUATION OF SPLENOMEGALY AND LIVER FIBROSIS FOUR YEARS AFTER MASS CHEMOTHERAPY WITH OXAMNIQUINE
Am J Trop Med Hyg, January 1, 2006; 74(1): 103 - 107.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society for Investigative Pathology.