This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Joshi, K. Articles by Monoghan, P. Search for Related Content PubMed PubMed Citation Articles by Joshi, K. Articles by Monoghan, P.

American Journal of Pathology, Vol 124, 199-206, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Cell proliferation in the human mammary epithelium. Differential contribution by epithelial and myoepithelial cells

K Joshi, JA Smith, N Perusinghe and P Monoghan

The ductal system of the human breast consists of epithelial, myoepithelial, and basal clear cells. By labeling ducts and alveoli dissected from reduction mammoplasty specimens with 3H-thymidine in vitro and labeling human breast organoids xenografted in nude mice in vivo, it was found that cellular proliferation in the human breast is virtually confined to epithelial and basal clear cells. A pulse label of 3H-thymidine in organ culture explants was followed over a period of time, and it was found that myoepithelial cells originate from a precursor cell population within the mammary epithelium after a number of cell divisions. Myoepithelial cells were not seen to divide when fully mature.

This article has been cited by other articles:

				A. K. Meeker, J. L. Hicks, E. Gabrielson, W. M. Strauss, A. M. De Marzo, and P. Argani Telomere Shortening Occurs in Subsets of Normal Breast Epithelium as well as in Situ and Invasive Carcinoma Am. J. Pathol., March 1, 2004; 164(3): 925 - 935. [Abstract] [Full Text] [PDF]

				Y. Hirako, K. Yoshino, D. Zillikens, and K. Owaribe Extracellular Cleavage of Bullous Pemphigoid Antigen 180/Type XVII Collagen and Its Involvement in Hemidesmosomal Disassembly J. Biochem., February 1, 2003; 133(2): 197 - 206. [Abstract] [Full Text] [PDF]

				S. Takahashi, S. Nakamura, K. Shinzato, T. Domon, T. Yamamoto, and M. Wakita Apoptosis and Proliferation of Myoepithelial Cells in Atrophic Rat Submandibular Glands J. Histochem. Cytochem., December 1, 2001; 49(12): 1557 - 1564. [Abstract] [Full Text] [PDF]

				H. Rahmoune, H.-L. Chen, J. T. Gallagher, P. S. Rudland, and D. G. Fernig Interaction of Heparan Sulfate from Mammary Cells with Acidic Fibroblast Growth Factor (FGF) and Basic FGF. REGULATION OF THE ACTIVITY OF BASIC FGF BY HIGH AND LOW AFFINITY BINDING SITES IN HEPARAN SULFATE J. Biol. Chem., March 27, 1998; 273(13): 7303 - 7310. [Abstract] [Full Text] [PDF]

				B Niranjan, L Buluwela, J Yant, N Perusinghe, A Atherton, D Phippard, T Dale, B Gusterson, and T Kamalati HGF/SF: a potent cytokine for mammary growth, morphogenesis and development Development, January 9, 1995; 121(9): 2897 - 2908. [Abstract] [PDF]