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American Journal of Pathology, Vol 124, 367-372, Copyright © 1986 by American Society for Investigative Pathology

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The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin

MI Cybulsky, IG Colditz and HZ Movat

Chemotactic factors induce neutrophil emigration into tissues. Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin. Kinetic studies revealed a rapid and transient neutrophil influx, with the peak rate at 30-90 minutes. Cross tachyphylaxis was observed between IL-1 and endotoxin; and this, together with its high potency and rapid onset of action, suggest that IL-1 mediates endotoxin-induced neutrophil emigration.

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