Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions

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Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions

AM Gown, T Tsukada and R Ross

The authors have performed immunocytochemical investigations of the distribution of various cell types in human atherosclerotic plaques using monoclonal antibodies specific to smooth muscle cells (CGA7 [Gown et al, J Cell Biol 1985, 100:807-813] and HHF35 [Tsukada et al, Am J Pathol (In press)] ); lymphocytes (T200 antigen); endothelial cells (Factor VIII and the Ulex europeus agglutinin); and macrophages, the latter with a new macrophage-specific antibody HAM56. All studies were performed on methanol-Carnoy's-fixed, paraffin-embedded tissues. In areas of grossly normal aorta, significant numbers of macrophages were noted within areas of diffuse intimal thickening. The cellular composition of the following three types of raised lesions were analyzed: fibro-fatty lesions, which, despite their gross appearance, consistent with fibrous plaques, were composed almost exclusively of macrophages and lymphocytes and almost devoid of smooth muscle cells; fibrous plaques, which were predominantly composed of smooth muscle cells displaying considerable morphologic heterogeneity and an admixture of blood-borne cells; advanced plaques, which were characterized by complex layers of smooth muscle cells and macrophages with considerable variation from region to region. Also noted were foci of medial and even intimal vascularization subjacent to the more advanced plaques. These studies demonstrate the application of monoclonal antibody technology to the study of the cellular composition of human atherosclerotic lesions.

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				A. Bobik and N. Kalinina Tumor Necrosis Factor Receptor and Ligand Superfamily Family Members TNFRSF14 and LIGHT: New Players in Human Atherogenesis Arterioscler. Thromb. Vasc. Biol., December 1, 2001; 21(12): 1873 - 1875. [Full Text] [PDF]

				T. M. Lincoln, N. Dey, and H. Sellak Signal Transduction in Smooth Muscle: Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression J Appl Physiol, September 1, 2001; 91(3): 1421 - 1430. [Abstract] [Full Text] [PDF]

				T. Sako, E. Uchida, Y. Kagawa, K. Hirayama, T. Takahashi, T. Nakade, M. Niiyama, Y. Izumisawa, and H. Taniyama Immunohistochemical Detection of Apolipoprotein B-100 and Immunoglobulins (IgA, IgM, IgG) in the Splenic Arteries of Aging Dogs Vet. Pathol., July 1, 2001; 38(4): 407 - 413. [Abstract] [Full Text] [PDF]

				S. Stemme Plaque T-Cell Activity : Not So Specific? Arterioscler. Thromb. Vasc. Biol., July 1, 2001; 21(7): 1099 - 1101. [Full Text] [PDF]

				F. L. Celletti, P. R. Hilfiker, P. Ghafouri, and M. D. Dake Effect of human recombinant vascular endothelial growth factor165 on progression of atherosclerotic plaque J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2126 - 2130. [Abstract] [Full Text] [PDF]

REGULAR ARTICLES

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions

				K. Aragane, K. Fujinami, K. Kojima, and J. Kusunoki ACAT inhibitor F-1394 prevents intimal hyperplasia induced by balloon injury in rabbits J. Lipid Res., April 1, 2001; 42(4): 480 - 488. [Abstract] [Full Text]

				B. B. Gowen, T. K. Borg, A. Ghaffar, and E. P. Mayer The collagenous domain of class A scavenger receptors is involved in macrophage adhesion to collagens J. Leukoc. Biol., April 1, 2001; 69(4): 575 - 582. [Abstract] [Full Text]

				C. Sundberg, J. A. Nagy, L. F. Brown, D. Feng, I. A. Eckelhoefer, E. J. Manseau, A. M. Dvorak, and H. F. Dvorak Glomeruloid Microvascular Proliferation Follows Adenoviral Vascular Permeability Factor/Vascular Endothelial Growth Factor-164 Gene Delivery Am. J. Pathol., March 1, 2001; 158(3): 1145 - 1160. [Abstract] [Full Text] [PDF]

				T. J. Tegos, E. Kalodiki, M. M. Sabetai, and A. N. Nicolaides The Genesis of Atherosclerosis and Risk Factors: A Review Angiology, February 1, 2001; 52(2): 89 - 98. [Abstract] [PDF]

				D. J. Falcone, W. Borth, K. M. F. Khan, and K. A. Hajjar Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II Blood, February 1, 2001; 97(3): 777 - 784. [Abstract] [Full Text] [PDF]

				P. G. Anderson, N. J. Boerth, M. Liu, D. B. McNamara, T. L. Cornwell, and T. M. Lincoln Cyclic GMP-Dependent Protein Kinase Expression in Coronary Arterial Smooth Muscle in Response to Balloon Catheter Injury Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2192 - 2197. [Abstract] [Full Text] [PDF]

				O. Belton, D. Byrne, D. Kearney, A. Leahy, and D. J. Fitzgerald Cyclooxygenase-1 and -2-Dependent Prostacyclin Formation in Patients With Atherosclerosis Circulation, August 22, 2000; 102(8): 840 - 845. [Abstract] [Full Text] [PDF]

				M. Hosono, M. Ueda, S. Suehiro, Y. Sasaki, T. Shibata, K. Hattori, and H. Kinoshita Neointimal formation at the sites of anastomosis of the internal thoracic artery grafts after coronary artery bypass grafting in human subjects: An immunohistochemical analysis J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 319 - 328. [Abstract] [Full Text] [PDF]

				S.-C. Lu, W.-H. Wu, C.-A. Lee, H.-F. Chou, H.-R. Lee, and P.-C. Huang LDL of Taiwanese Vegetarians Are Less Oxidizable than Those of Omnivores J. Nutr., June 1, 2000; 130(6): 1591 - 1596. [Abstract] [Full Text]

				J. Feng, J. Han, S. F. A. Pearce, R. L. Silverstein, A. M. Gotto , Jr., David. P. Hajjar, and A. C. Nicholson Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-{gamma} J. Lipid Res., May 1, 2000; 41(5): 688 - 696. [Abstract] [Full Text]