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American Journal of Pathology, Vol 125, 28-34, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Modulation of murine schistosomiasis by exogenously administered prostaglandins

SW Chensue, DG Remick, GI Higashi, DL Boros and SL Kunkel

The effect of parenteral administration of prostaglandins, 15-(s)-15- methyl PGE1 (M-PGE) and PGF2 alpha (PGF) on the pathophysiologic manifestations of active murine Schistosoma mansoni infection was examined. Both M-PGE and PGF resulted in a nearly 50% suppression of granuloma size following a 7-day course of treatment. M-PGE and PGF appeared to act by different mechanisms. The former caused a broad- spectrum immunosuppression manifested as reduced splenomegaly, B-cell proliferation, and antigen-specific interleukin-2 (IL-2) production as well as decreased granuloma macrophage Ia antigen expression, superoxide anion (O2-) production, and interleukin-1 (IL-1) production. In contrast, PGF did not ameliorate splenomegaly, but caused increases in splenic asialo-GM1 (natural killer cells) and L3T4 (helper) positive T cells. Prostaglandin F also reduced IL-2 production, but to a lesser extent that M-PGE. Although PGF caused reduced granuloma macrophage Ia expression and O2- production, it did not suppress IL-1 production. Overall, these data show that PGs can significantly modulate immunopathologic events in chronic granulomatous disease states.


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A. B. Stavitsky
Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis
Infect. Immun., January 1, 2004; 72(1): 1 - 12.
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Copyright © 1986 by the American Society for Investigative Pathology.