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American Journal of Pathology, Vol 125, 90-96, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Induction of HLA-DR antigen expression in human endometrial epithelial cells in vitro by recombinant gamma-interferon

SS Tabibzadeh, MA Gerber and PG Satyaswaroop

Recent studies suggest that HLA-DR antigens may be inducible in some normal epithelial cells. Therefore, we studied the expression of these molecules in epithelial cell cultures derived from 9 proliferative and 7 secretory endometria with and without treatment by recombinant gamma- interferon (gamma-IFN). A panel of monoclonal antibodies to HLA-DR antigens, T cells, B cells, macrophages, endothelial cells, and cytokeratin was used to stain the cultured cells by the avidin-biotin complex method. The cultures consisted only of epithelial cells as demonstrated by expression of cytokeratin and by electron microscopy and did not contain any T or B cells, macrophages, or endothelial cells. The endometrial epithelial cells were HLA-DR-negative under routine culture conditions but expressed HLA-DR antigens after gamma- IFN treatment in a dose- and time-dependent fashion. The findings indicate that endometrial epithelium can actively synthesize HLA-DR antigens in vitro after induction by gamma-IFN.


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Copyright © 1986 by the American Society for Investigative Pathology.