help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hsu, S. M.
Right arrow Articles by Zhao, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hsu, S. M.
Right arrow Articles by Zhao, X.

American Journal of Pathology, Vol 125, 221-225, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of interleukin-1 in Reed-Sternberg cells and neoplastic cells from true histiocytic malignancies

SM Hsu and X Zhao

Interleukin-1, a peptide produced by monocytes, histiocytes, and interdigitating reticulum cells, plays an important role in the regulation of immune function. In this styde, we examined the production of interleukin-1 in 115 patients with a variety of human lymphomas by using a rabbit anti-interleukin-1 antibody and the immunoperoxidase technique. Interleukin-1 was detected in Reed- Sternberg cells from 20 patients with Hodgkin's disease as well as in neoplastic cells from 9 patients with true histiocytic lymphoma or malignant histiocytosis. In the other 86 cases, which included T- and B- cell lymphomas, no interleukin-1 could be detected. This result indicates a close relationship between Hodgkin's disease and true histiocytic malignancies and provides additional evidence to support our hypothesis that Reed-Sternberg cells are related to interdigitating reticulum cells.


This article has been cited by other articles:


Home page
 BloodHome page
B. F. Skinnider and T. W. Mak
The role of cytokines in classical Hodgkin lymphoma
Blood, May 29, 2002; 99(12): 4283 - 4297.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Oelmann, H. Herbst, M. Zuhlsdorf, O. Albrecht, A. Nolte, C. Schmitmann, O. Manzke, V. Diehl, H. Stein, and W. E. Berdel
Tissue inhibitor of metalloproteinases 1 is an autocrine and paracrine survival factor, with additional immune-regulatory functions, expressed by Hodgkin/Reed-Sternberg cells
Blood, January 1, 2002; 99(1): 258 - 267.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Jundt, I. Anagnostopoulos, K. Bommert, F. Emmerich, G. Muller, H.-D. Foss, H.-D. Royer, H. Stein, and B. Dorken
Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils
Blood, September 15, 1999; 94(6): 2065 - 2071.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society for Investigative Pathology.