help button home button Am J Pathol The FASEB Journal
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Samoszuk, M. K.
Right arrow Articles by Lukes, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Samoszuk, M. K.
Right arrow Articles by Lukes, R. J.

American Journal of Pathology, Vol 125, 426-429, Copyright © 1986 by American Society for Investigative Pathology

REGULAR ARTICLES

Extensive deposition of eosinophil peroxidase in Hodgkin's and non- Hodgkin's lymphomas

MK Samoszuk, BN Nathwani and RJ Lukes

To determine whether occult eosinophil degranulation occurs in lymphomas, the authors performed immunohistologic and cytochemical studies on cryostat sections from 25 consecutive lymph node biopsies. A glucose-oxidase immunohistochemical technique was employed with a murine monoclonal antibody specific for human eosinophil peroxidase (EPO). In 7 cases of Hodgkin's disease, 3 cases of T-immunoblastic sarcoma, and 1 case of small cleaved follicular center cell lymphoma with sclerosis, there was extensive and striking extracellular deposition of EPO in a granular and fibrillar pattern within the connective tissue. Similar degranulation of eosinophils was not observed in any of the benign lymph node specimens or other B-cell lymphomas. It is concluded that eosinophils extensively degranulate and release EPO in some types of lymphoma.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
M. Samoszuk, T. Deng, M. J. Hamamura, M.-Y. Su, N. Asbrock, and O. Nalcioglu
Increased Blood Clotting, Microvascular Density, and Inflammation in Eotaxin-Secreting Tumors Implanted into Mice
Am. J. Pathol., August 1, 2004; 165(2): 449 - 456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. C. MacPherson, S. A. A. Comhair, S. C. Erzurum, D. F. Klein, M. F. Lipscomb, M. S. Kavuru, M. K. Samoszuk, and S. L. Hazen
Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species
J. Immunol., May 1, 2001; 166(9): 5763 - 5772.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Ali, J. Kaur, and K. D. Patel
Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Regulated on Activation Normal T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil Adhesion and Activation
Am. J. Pathol., July 1, 2000; 157(1): 313 - 321.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society for Investigative Pathology.