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American Journal of Pathology, Vol 125, 460-464, Copyright © 1986 by American Society for Investigative Pathology

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Amyloid P component is not present in the glomerular basement membrane in Alport-type hereditary nephritis

T Melvin, Y Kim and AF Michael

Serum amyloid P component (SAP) is a normal plasma glycoprotein immunochemically indistinguishable from amyloid P, a glycoprotein found in all tissue amyloid deposits. SAP has also been shown to be a constituent of normal glomerular basement membrane (GBM). In this study the authors discovered a unique association between SAP and Goodpasture (GP) antigen. In those patients whose GBM lack GP antigen (those with Alport-type hereditary nephritis) SAP is also uniformly absent. Although the relationship between these two components is unknown, this association may provide clues to the abnormality of GBM in Alport-type hereditary nephritis.

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