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American Journal of Pathology, Vol 126, 561-568, Copyright © 1987 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin

AG Farr, JW Mannschreck and SK Anderson

In the normal murine kidney, Ia antigens are expressed by dendritic cells located within the interstitial connective tissue and scattered cells within the glomerulus. After receiving multiple low doses of streptozotocin, a nitrosourea derivative of glucose, kidney epithelium labeled intensely with anti-Ia antibodies. Ultrastructural immunohistochemistry indicated that the epithelial cells of the proximal convoluted tubules expressed Ia antigens on their basolateral surfaces while remaining Ia- on their luminal surfaces. This response to streptozotocin does not appear to be related to the diabetogenic potential of the drug, because BALB/cJ mice, which remain normoglycemic after treatment with streptozotocin, also exhibited strongly Ia+ tubular epithelium after treatment with streptozotocin.


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Copyright © 1987 by the American Society for Investigative Pathology.