This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nawaz, S. Articles by Gerschenson, L. E. Search for Related Content PubMed PubMed Citation Articles by Nawaz, S. Articles by Gerschenson, L. E.

American Journal of Pathology, Vol 127, 51-59, Copyright © 1987 by American Society for Investigative Pathology

REGULAR ARTICLES

Hormonal regulation of cell death in rabbit uterine epithelium

S Nawaz, MP Lynch, P Galand and LE Gerschenson

It is known that estrogen (E) and progesterone (P) play important roles in the regulation of endometrial growth. In the rabbit endometrial epithelium, a balance is maintained between cell proliferation and cell death which seems to be under ovarian hormonal control. In this study the authors determined cell proliferation by quantitating the mitotic index (MI) and cell death by quantitating the death index (DI) in uterine histologic sections from whole animals that were hormone treated versus control rabbits. E caused proliferation of uterine epithelial cells and decreased the DI transiently, while P also increased proliferation but decreased the DI dramatically. In a time course study, after a single injection of human chorionic gonadotropin to induce pseudopregnancy, there was transient decrease in the DI and an increase in the MI between Days 2 and 5. In pseudopregnant animals, hormones had no effect in intact animals, but after ovariectomy there was about a 124-fold increase in the DI, which could be prevented by P administration. The predominant type of cell death observed in this system is apoptosis (97.5%), as opposed to necrosis (2.5%). Thus, it is proposed that cell death may be as important as cell proliferation in the regulation of normal uterine epithelial growth.

This article has been cited by other articles:

				Y. Yin, W.-W. Huang, C. Lin, H. Chen, A. MacKenzie, and L. Ma Estrogen Suppresses Uterine Epithelial Apoptosis by Inducing Birc1 Expression Mol. Endocrinol., January 1, 2008; 22(1): 113 - 125. [Abstract] [Full Text] [PDF]

				B. Wang, C. Xiao, and A. K. Goff Progesterone-Modulated Induction of Apoptosis by Interferon-Tau in Cultured Epithelial Cells of Bovine Endometrium Biol Reprod, February 1, 2003; 68(2): 673 - 679. [Abstract] [Full Text] [PDF]

				C. SIMON, F. DOMINGUEZ, J. REMOHI, and A. PELLICER Embryo Effects in Human Implantation: Embryonic Regulation of Endometrial Molecules in Human Implantation Ann. N.Y. Acad. Sci., September 1, 2001; 943(1): 1 - 16. [Abstract] [Full Text] [PDF]

				K. D. Burroughs, R. Fuchs-Young, B. Davis, and C. L. Walker Altered Hormonal Responsiveness of Proliferation and Apoptosis During Myometrial Maturation and the Development of Uterine Leiomyomas in the Rat Biol Reprod, November 1, 2000; 63(5): 1322 - 1330. [Abstract] [Full Text]

				A. Galán, J. E. O'Connor, D. Valbuena, R. Herrer, J. Remohí, S. Pampfer, A. Pellicer, and C. Simón The Human Blastocyst Regulates Endometrial Epithelial Apoptosis in Embryonic Adhesion Biol Reprod, August 1, 2000; 63(2): 430 - 439. [Abstract] [Full Text]

				K. P. Nephew, E. Osborne, R. A. Lubet, C. J. Grubbs, and S. A. Khan Effects of Oral Administration of Tamoxifen, Toremifene, Dehydroepiandrosterone, and Vorozole on Uterine Histomorphology in the Rat Experimental Biology and Medicine, March 1, 2000; 223(3): 288 - 294. [Abstract] [Full Text]

				S. B. Wade, P. Oommen, W. C. Conner, D. J. Earnest, and R. C. Miranda Overlapping and Divergent Actions of Estrogen and the Neurotrophins on Cell Fate and p53-Dependent Signal Transduction in Conditionally Immortalized Cerebral Cortical Neuroblasts J. Neurosci., August 15, 1999; 19(16): 6994 - 7006. [Abstract] [Full Text] [PDF]

				M. Dahmoun, K. Boman, S. Cajander, P. Westin, and T. Bäckström Apoptosis, Proliferation, and Sex Hormone Receptors in Superficial Parts of Human Endometrium at the End of the Secretory Phase J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1737 - 1743. [Abstract] [Full Text]

				A. Pecci, A. Scholz, D. Pelster, and M. Beato Progestins Prevent Apoptosis in a Rat Endometrial Cell Line and Increase the Ratio of bcl-XL to bcl-XS J. Biol. Chem., May 2, 1997; 272(18): 11791 - 11798. [Abstract] [Full Text] [PDF]