help button home button Am J Pathol ASIP MEMBERSHIP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zook, B. C.
Right arrow Articles by Hertz, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zook, B. C.
Right arrow Articles by Hertz, R.

American Journal of Pathology, Vol 128, 315-327, Copyright © 1987 by American Society for Investigative Pathology

REGULAR ARTICLES

Malignant neoplasms of decidual origin (deciduosarcomas) induced by estrogen-progestin-releasing intravaginal devices in rabbits

BC Zook, I Spiro and R Hertz

A combination of estrogen and levonorgestrel was continuously delivered to 23 adult rabbits for up to 2 years via a Silastic ring device sutured into the vagina. Twenty-one control rabbits were given similar rings devoid of drugs. A marked decidual reaction of the endometrium occurred in 16 of 23 test rabbits. In 14 test rabbits (61%) malignant tumors developed of decidual type cells not heretofore described. The deciduosarcomas were composed of anaplastic cells that invaded the uterine walls, uterine lymphatics, and in 4 of 13 (31%) rabbits that survived 2 years of treatment, the tumors metastasized to the lungs. Several deciduosarcomas appeared to arise within the spleen or other abdominal organs. Other drug-related lesions included uterine or vaginal polyps, endometrial atrophy, and focal necrosis and mineralization of the uterine wall. Cells from several deciduosarcomas failed to produce tumors in nude mice or to colonize on soft agar. No decidualization or decidual neoplasms were seen in the controls.


This article has been cited by other articles:


Home page
 Vet PatholHome page
M. Goto, Y. Nomura, Y. Une, and M. H. Goldschmidt
Malignant Mixed Mullerian Tumor in a Rabbit (Oryctolagus cuniculus): Case Report with Immunohistochemistry.
Vet. Pathol., July 1, 2006; 43(4): 560 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
T. K. Cooper, D. Adelsohn, and S. R. Gilbertson
Spontaneous Deciduosarcoma in a Domestic Rabbit (Oryctolagus cuniculus)
Vet. Pathol., May 1, 2006; 43(3): 377 - 380.
[Abstract] [Full Text] [PDF]

Home page
 J Wildl DisHome page
C. Jardine, G. A. Wobeser, and E. Simko
Malignant Mesenchymal Tumors in Two White-tailed Jack Rabbits (Lepus townsendii)
J. Wildl. Dis., October 1, 2004; 40(4): 754 - 758.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
B. C. Zook, O. A. Janne, A. A. Abraham, and H. A. Nash
The Development and Regression of Deciduosarcomas and Other Lesions Caused by Estrogens and Progestins in Rabbits
Toxicol Pathol, June 1, 2001; 29(4): 411 - 416.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
O. A. Janne, B. C. Zook, A. K. Didolkar, K. Sundaram, and H. A. Nash
The Roles of Estrogen and Progestin in Producing Deciduosarcoma and Other Lesions in the Rabbit
Toxicol Pathol, June 1, 2001; 29(4): 417 - 421.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
E. Karbe
Review Article: "Mesenchymal Tumor" or "Decidual-Like Reaction"?
Toxicol Pathol, May 1, 1999; 27(3): 354 - 362.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by the American Society for Investigative Pathology.