This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smith, M. W. Articles by Tivey, D. R. Search for Related Content PubMed PubMed Citation Articles by Smith, M. W. Articles by Tivey, D. R.

American Journal of Pathology, Vol 128, 385-389, Copyright © 1987 by American Society for Investigative Pathology

REGULAR ARTICLES

M cell numbers increase after transfer of SPF mice to a normal animal house environment

MW Smith, PS James and DR Tivey

M cells present in the follicle-associated epithelium (FAE) of mouse Peyer's patches take up and transport enteric antigens to the underlying gut-associated lymphoid tissue (GALT) for subsequent processing by lymphocytes and macrophages. Present experiments use a new type of cell-labeling technique in attempts to measure the number of M cells present in the FAE of specific pathogen-free (SPF) and normal animal house reared (AH) BALB/c mice. Results show the apparent M-cell area to increase threefold 7 days after transfer of SPF mice to an AH environment. This change takes place without significantly affecting the area of FAE occupied by goblet cells. It is suggested from these results that M-cell production can be selectively increased within the FAE through the presence of foreign antigens and that this effect could have general importance in controlling the overall GALT response to enteric infection.

This article has been cited by other articles:

				T. Yamanaka, L. Helgeland, I. N. Farstad, H. Fukushima, T. Midtvedt, and P. Brandtzaeg Microbial Colonization Drives Lymphocyte Accumulation and Differentiation in the Follicle-Associated Epithelium of Peyer's Patches J. Immunol., January 15, 2003; 170(2): 816 - 822. [Abstract] [Full Text] [PDF]

				T. Nakayama, R. Fujisawa, H. Yamada, T. Horikawa, H. Kawasaki, K. Hieshima, D. Izawa, S. Fujiie, T. Tezuka, and O. Yoshie Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3{{alpha}}/CCL20 by epidermal keratinocytes and its role in atopic dermatitis Int. Immunol., January 1, 2001; 13(1): 95 - 103. [Abstract] [Full Text] [PDF]

				C NICOLETTI Unsolved mysteries of intestinal M cells Gut, November 1, 2000; 47(5): 735 - 739. [Full Text] [PDF]

				H. M. MEYNELL, N. W. THOMAS, P. S. JAMES, J. HOLLAND, M. J. TAUSSIG, and C. NICOLETTI Up-regulation of microsphere transport across the follicle-associated epithelium of Peyer's patch by exposure to Streptococcus pneumoniae R36a FASEB J, April 1, 1999; 13(6): 611 - 619. [Abstract] [Full Text]

				M. R. Neutra V. Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system Am J Physiol Gastrointest Liver Physiol, May 1, 1998; 274(5): G785 - G791. [Abstract] [Full Text] [PDF]