help button home button Am J Pathol Angiogenesis Meeting
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scarpa, S.
Right arrow Articles by Triche, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scarpa, S.
Right arrow Articles by Triche, T. J.

American Journal of Pathology, Vol 129, 74-85, Copyright © 1987 by American Society for Investigative Pathology

REGULAR ARTICLES

Extracellular matrix synthesis by undifferentiated childhood tumor cell lines

S Scarpa, A Modesti and TJ Triche
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892.

The authors have examined extracellular matrix (ECM) biosynthesis by small round cell tumors of childhood. Basal lamina (laminin and Type IV collagen) and stroma (collagens I, III, and V and fibronectin) constituents were studied. It was found that these tumors synthesize ECM in characteristic patterns. Five Ewing's sarcomas variably synthesized small amounts of all ECM constituents except Type V collagen. All eight neural tumors (neuroblastoma and primitive neural tumors) synthesized fibronectin (unlike some Ewing's sarcomas), as well as laminin and Type IV collagen (2 cases lacked Type IV collagen synthesis). No stromal (I/III) collagen synthesis was observed by neural tumors. All soft tissue sarcomas except an embryonal rhabdomyosarcoma synthesized stromal collagens and often laminin or fibronectin as well. Lymphomas synthesized no ECM of any kind. The synthesis of stromal collagens by sarcomas but not neural tumors serves to distinguish these two tumor types, especially Ewing's sarcoma from neuroblastoma. The presence of any ECM synthesis excludes lymphoma from diagnostic consideration.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
G. Raschell, A. Negroni, A. Sala, S. Pucci, A. Romeo, and B. Calabretta
Requirement of B- myb Function for Survival and Differentiative Potential of Human Neuroblastoma Cells
J. Biol. Chem., April 14, 1995; 270(15): 8540 - 8545.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by the American Society for Investigative Pathology.