This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Parsons, P. E. Articles by Henson, P. M. Search for Related Content PubMed PubMed Citation Articles by Parsons, P. E. Articles by Henson, P. M.

American Journal of Pathology, Vol 129, 302-312, Copyright © 1987 by American Society for Investigative Pathology

REGULAR ARTICLES

The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability

PE Parsons, K Sugahara, GR Cott, RJ Mason and PM Henson
Department of Medicine, National Immunology and Respiratory Medicine, Denver, CO 80206.

The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability was examined. Although neutrophil migration was not associated with a change in epithelial permeability, prolonged neutrophil-epithelial contact following migration resulted in an increase in epithelial permeability. These results were not altered by catalase, a specific neutrophil elastase inhibitor, methoxysuccinyl-Ala- Ala-Pro-Val-chloromethyl ketone or cyclohexamide. This suggests that neutrophil migration does not occur via an H2O2-induced reversible mechanism of junctional opening, which we describe herein.

This article has been cited by other articles:

				A. M. Kaynar, A. M. Houghton, E. H. Lum, B. R. Pitt, and S. D. Shapiro Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury Am. J. Respir. Cell Mol. Biol., July 1, 2008; 39(1): 53 - 60. [Abstract] [Full Text] [PDF]

				A. C CHIN and C. A PARKOS Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD: Potential Targets for Inhibiting Neutrophil Trafficking. Ann. N.Y. Acad. Sci., August 1, 2006; 1072: 276 - 287. [Abstract] [Full Text] [PDF]

				G. Allen and J. H. T. Bates Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury J Appl Physiol, January 1, 2004; 96(1): 293 - 300. [Abstract] [Full Text] [PDF]

				W. E. Smith, A. V. Kane, S. T. Campbell, D. W. K. Acheson, B. H. Cochran, and C. M. Thorpe Shiga Toxin 1 Triggers a Ribotoxic Stress Response Leading to p38 and JNK Activation and Induction of Apoptosis in Intestinal Epithelial Cells Infect. Immun., March 1, 2003; 71(3): 1497 - 1504. [Abstract] [Full Text] [PDF]

				H. A. Edens, B. P. Levi, D. L. Jaye, S. Walsh, T. A. Reaves, J. R. Turner, A. Nusrat, and C. A. Parkos Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration J. Immunol., July 1, 2002; 169(1): 476 - 486. [Abstract] [Full Text] [PDF]

				C. M. Thorpe, W. E. Smith, B. P. Hurley, and D. W. K. Acheson Shiga Toxins Induce, Superinduce, and Stabilize a Variety of C-X-C Chemokine mRNAs in Intestinal Epithelial Cells, Resulting in Increased Chemokine Expression Infect. Immun., October 1, 2001; 69(10): 6140 - 6147. [Abstract] [Full Text] [PDF]

				T. W. Liang, R. A. DeMarco, R. J. Mrsny, A. Gurney, A. Gray, J. Hooley, H. L. Aaron, A. Huang, T. Klassen, D. B. Tumas, et al. Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1733 - C1743. [Abstract] [Full Text] [PDF]

				L. B. Balsam, T. W. Liang, and C. A. Parkos Functional Mapping of CD11b/CD18 Epitopes Important in Neutrophil-Epithelial Interactions: A Central Role of the I Domain J. Immunol., May 15, 1998; 160(10): 5058 - 5065. [Abstract] [Full Text] [PDF]