This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rubio, C. A. Articles by Kato, Y. Search for Related Content PubMed PubMed Citation Articles by Rubio, C. A. Articles by Kato, Y.

American Journal of Pathology, Vol 130, 485-488, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

DNA profiles in mitotic cells from gastric adenomas

CA Rubio and Y Kato
Department of Pathology, Karolinska Institute, Stockholm, Sweden.

Quantitative DNA measurements were done in mitotic figures from 17 gastric adenomas having slight (3 cases), moderate (8 cases), or severe dysplasia (3 cases) or foci of invasive adenocarcinoma (3 cases). Values higher than for normal diploid control cells (2c) or their estimated tetraploid values (4c) were found to increase gradually from slight dysplasia to invasive adenocarcinoma through moderate and severe dysplasia. While none of the adenomas having slight or moderate dysplasia demonstrated aneuploid mitoses (ie, values higher than 5c), 1% of the mitoses in severe dysplasia and 27% of those with invasive adenocarcinoma had values higher than 5c. The present results thus suggest that aneuploid mitotic figures may help to recognize those gastric adenomas having invasive growth.

This article has been cited by other articles:

				C. A Rubio My approach to reporting a gastric biopsy J. Clin. Pathol., February 1, 2007; 60(2): 160 - 166. [Abstract] [Full Text] [PDF]