This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goldman, J. E. Articles by Corbin, E. Search for Related Content PubMed PubMed Citation Articles by Goldman, J. E. Articles by Corbin, E.

American Journal of Pathology, Vol 130, 569-578, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

Isolation of a major protein component of Rosenthal fibers

JE Goldman and E Corbin
Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, New York.

Rosenthal fibers (RFs) are inclusions within astrocytes, characteristic of Alexander's disease, but also seen in astrocytic tumors and occasionally in glial scar tissue. They are granular deposits, intimately associated with intermediate filaments. Their composition has been unknown. The authors have isolated a protein of about 19 kd from partially purified RFs from Alexander's disease central nervous system tissue. Antibodies were raised to this protein and shown to react with it on nitrocellulose blots and to bind to RFs in tissue sections. Small amounts of this protein were detected in normal brain and in cultured rat astrocytes. Charge heterogeneity was inferred because several species were separated by isoelectric focusing.

This article has been cited by other articles:

				G. Tang, Z. Yue, Z. Talloczy, T. Hagemann, W. Cho, A. Messing, D. L. Sulzer, and J. E. Goldman Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways Hum. Mol. Genet., June 1, 2008; 17(11): 1540 - 1555. [Abstract] [Full Text] [PDF]

				F.J. Wippold II, A. Perry, and J. Lennerz Neuropathology for the neuroradiologist: rosenthal fibers. AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 958 - 961. [Abstract] [Full Text] [PDF]

				R. Tian, M. Gregor, G. Wiche, and J. E. Goldman Plectin Regulates the Organization of Glial Fibrillary Acidic Protein in Alexander Disease Am. J. Pathol., March 1, 2006; 168(3): 888 - 897. [Abstract] [Full Text] [PDF]

				V. C. Hsiao, R. Tian, H. Long, M. Der Perng, M. Brenner, R. A. Quinlan, and J. E. Goldman Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP J. Cell Sci., May 1, 2005; 118(9): 2057 - 2065. [Abstract] [Full Text] [PDF]

				M. Samuel, N. Torun, P. J. Tuite, J. A. Sharpe, and A. E. Lang Progressive ataxia and palatal tremor (PAPT): Clinical and MRI assessment with review of palatal tremors Brain, June 1, 2004; 127(6): 1252 - 1268. [Abstract] [Full Text] [PDF]