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American Journal of Pathology, Vol 131, 38-47, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

Peliosis hepatis and sinusoidal dilation during infection by the human immunodeficiency virus (HIV). An ultrastructural study

JY Scoazec, C Marche, PM Girard, J Houtmann, AM Durand-Schneider, AG Saimot, JP Benhamou and G Feldmann
Laboratoire d'Histologie et de Biologie Cellulaire, Hopital Bichat, Paris, France.

The description of hepatic sinusoidal lesions in a significant number of acquired immunodeficiency syndrome (AIDS) patients prompted the authors to undertake an ultrastructural study of the sinusoidal barrier abnormalities during human immunodeficiency virus (HIV) infection, in order to compare these lesions with those described in other conditions and to discuss their possible origin. In a series of 29 patients with serologic evidence of HIV infection and liver abnormalities, 8 (28%) had sinusoidal lesions. Peliosis hepatis was present in 2 cases, and sinusoidal dilatation in 6. These patients were classified as follows: 3 AIDS, 4 AIDS-related complex, 1 unclassifiable. Ultrastructural lesions of the sinusoidal barrier were observed in all the cases. They closely mimicked the changes previously reported in peliotic and peliotic-like changes of various origins. A striking particularity was, however, the presence of numerous and hyperplastic sinusoidal macrophages. This work suggests that an injury of the endothelial cells, directly or indirectly related to the presence of HIV, may be incriminated in the pathogenesis of sinusoidal lesions during HIV infection.


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D Saadoun, D Cazals-Hatem, M-H Denninger, L Boudaoud, B-N Pham, V Mallet, B Condat, J Briere, and D Valla
Association of idiopathic hepatic sinusoidal dilatation with the immunological features of the antiphospholipid syndrome
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Copyright © 1988 by the American Society for Investigative Pathology.