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American Journal of Pathology, Vol 131, 84-91, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus

CA Hanson, G Frizzera, DF Patton, BA Peterson, KL McClain, KJ Gajl-Peczalska and JH Kersey
Department of laboratory Medicine and Pathology, University of Minnesota Hospital Clinic, Minneapolis.

Castleman's disease is a morphologically and clinically heterogeneous lymphoproliferative disorder. Both a localized benign variant and an aggressive form with systemic manifestations have been described. To investigate the differences between these variants of Castleman's disease, the authors analyzed lymph node DNA from 4 patients with the localized type and 4 with the systemic type of Castleman's disease for immunoglobulin and T-cell receptor gene rearrangements. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) was also studied by viral genomic DNA probes. They detected clonal rearrangements in 3 of the 4 patients with the systemic variant of Castleman's; no patients with localized disease had rearrangements. Copies of EBV genome were also detected in 2 of the 3 patients with clonal rearrangements. These results suggest that systemic Castleman's disease is a disorder distinct from the classical localized variant in that it may evolve into a clonal lymphoproliferation.


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Copyright © 1988 by the American Society for Investigative Pathology.