| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 132, 86-101, Copyright © 1988 by American Society for Investigative Pathology
REGULAR ARTICLES |
DW Dickson, J Farlo, P Davies, H Crystal, P Fuld and SH Yen
Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY 10461.
The senile plaque is one of the histopathologic changes that characterizes Alzheimer's disease and the aging brain. The histopathology of senile plaques was studied using double-labeling immunohistochemistry and lectin histochemistry with thioflavin S fluorescent microscopy in 9 cases of Alzheimer's disease, 2 nondemented elderly individuals, and 3 individuals with non-Alzheimer primary degenerative dementias. Every plaque that was visualized with thioflavin also had amyloid, but not all thioflavin-positive plaques contained neurites that could be recognized with specific monoclonal antibodies to paired helical filament, tau, or neurofilament epitopes. Some neurofilament-positive neurites were not visualized with thioflavin, but almost all tau-positive neurites were colabeled with thioflavin. Microglia were associated with most plaques. Most plaques were also surrounded by fibrous astrocytes. These results suggest that amyloid may be the common feature that defines senile plaques, but that other elements may be more specific for Alzheimer's disease, because extensive neuritic degeneration was seen only in Alzheimer brains and not in either nondemented elderly individuals with senile plaques or in non-Alzheimer dementia cases.
This article has been cited by other articles:
 |
|
 |
|
  M.-M. Mocanu, A. Nissen, K. Eckermann, I. Khlistunova, J. Biernat, D. Drexler, O. Petrova, K. Schonig, H. Bujard, E. Mandelkow, et al. The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy J. Neurosci., January 16, 2008; 28(3): 737 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. McConlogue, M. Buttini, J. P. Anderson, E. F. Brigham, K. S. Chen, S. B. Freedman, D. Games, K. Johnson-Wood, M. Lee, M. Zeller, et al. Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice J. Biol. Chem., September 7, 2007; 282(36): 26326 - 26334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mouri, Y. Noda, H. Hara, H. Mizoguchi, T. Tabira, and T. Nabeshima Oral vaccination with a viral vector containing A{beta} cDNA attenuates age-related A{beta} accumulation and memory deficits without causing inflammation in a mouse Alzheimer model FASEB J, July 1, 2007; 21(9): 2135 - 2148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Thal, E. Capetillo-Zarate, K. Del Tredici, and H. Braak The Development of Amyloid beta Protein Deposits in the Aged Brain Sci. Aging Knowl. Environ., March 8, 2006; 2006(6): re1 - re1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rossi, L. Brambilla, C. F. Valori, A. Crugnola, G. Giaccone, R. Capobianco, M. Mangieri, A. E. Kingston, A. Bloc, P. Bezzi, et al. Defective Tumor Necrosis Factor-{alpha}-dependent Control of Astrocyte Glutamate Release in a Transgenic Mouse Model of Alzheimer Disease J. Biol. Chem., December 23, 2005; 280(51): 42088 - 42096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Ramirez, C. Blazquez, T. G. del Pulgar, M. Guzman, and M. L. de Ceballos Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation J. Neurosci., February 23, 2005; 25(8): 1904 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rentzos, M. Michalopoulou, C. Nikolaou, C. Cambouri, A. Rombos, A. Dimitrakopoulos, E. Kapaki, and D. Vassilopoulos Serum Levels of Soluble Intercellular Adhesion Molecule-1 and Soluble Endothelial Leukocyte Adhesion Molecule-1 in Alzheimer's Disease J Geriatr Psychiatry Neurol, December 1, 2004; 17(4): 225 - 231. [Abstract] [PDF]
|
|
|
|
|
|
V. Beglopoulos, X. Sun, C. A Saura, C. A. Lemere, R. D. Kim, and J. Shen Reduced {beta}-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knock-out Mice J. Biol. Chem., November 5, 2004; 279(45): 46907 - 46914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bussiere, F. Bard, R. Barbour, H. Grajeda, T. Guido, K. Khan, D. Schenk, D. Games, P. Seubert, and M. Buttini Morphological Characterization of Thioflavin-S-Positive Amyloid Plaques in Transgenic Alzheimer Mice and Effect of Passive A{beta} Immunotherapy on Their Clearance Am. J. Pathol., September 1, 2004; 165(3): 987 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kowa, T. Sakakura, Y. Matsuura, T. Wakabayashi, D. M.A. Mann, K. Duff, S. Tsuji, T. Hashimoto, and T. Iwatsubo Mostly Separate Distributions of CLAC- versus A{beta}40- or Thioflavin S-Reactivities in Senile Plaques Reveal Two Distinct Subpopulations of {beta}-Amyloid Deposits Am. J. Pathol., July 1, 2004; 165(1): 273 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Reyes, M. A. Chacon, M. C. Dinamarca, W. Cerpa, C. Morgan, and N. C. Inestrosa Acetylcholinesterase-A{beta} Complexes Are More Toxic than A{beta} Fibrils in Rat Hippocampus: Effect on Rat {beta}-Amyloid Aggregation, Laminin Expression, Reactive Astrocytosis, and Neuronal Cell Loss Am. J. Pathol., June 1, 2004; 164(6): 2163 - 2174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. El Khoury, K. J. Moore, T. K. Means, J. Leung, K. Terada, M. Toft, M. W. Freeman, and A. D. Luster CD36 Mediates the Innate Host Response to {beta}-Amyloid J. Exp. Med., June 16, 2003; 197(12): 1657 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Weidenheim, L. Goodman, D. W. Dickson, C. Gillberg, M. Rastam, and I. Rapin Etiology and Pathophysiology of Autistic Behavior: Clues From Two Cases With an Unusual Variant of Neuroaxonal Dystrophy J Child Neurol, January 1, 2001; 16(11): 809 - 819. [Abstract] [PDF]
|
|
|
|
|
|
T. V. Petrova, K. T. Akama, and L. J. Van Eldik Selective Modulation of BV-2 Microglial Activation by Prostaglandin E2. DIFFERENTIAL EFFECTS ON ENDOTOXIN-STIMULATED CYTOKINE INDUCTION J. Biol. Chem., October 1, 1999; 274(40): 28823 - 28827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kaltschmidt, M. Uherek, H. Wellmann, B. Volk, and C. Kaltschmidt Inhibition of NF-kappa B potentiates amyloid beta -mediated neuronal apoptosis PNAS, August 3, 1999; 96(16): 9409 - 9414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Dickson Microglia in Alzheimer's Disease and Transgenic Models : How Close the Fit? Am. J. Pathol., June 1, 1999; 154(6): 1627 - 1631. [Full Text] [PDF]
|
|
|
|
|
|
T. V. Petrova, K. T. Akama, and L. J. Van Eldik Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta 12,14-prostaglandin J2 PNAS, April 13, 1999; 96(8): 4668 - 4673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Uchihara, H. Akiyama, H. Kondo, and K. Ikeda Activated Microglial Cells Are Colocalized With Perivascular Deposits of Amyloid-{beta} Protein in Alzheimer's Disease Brain Stroke, October 1, 1997; 28(10): 1948 - 1950. [Abstract] [Full Text]
|
|
|
|
|
|
E. Masliah, A. Sisk, M. Mallory, L. Mucke, D. Schenk, and D. Games Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F beta -Amyloid Precursor Protein and Alzheimer's Disease J. Neurosci., September 15, 1996; 16(18): 5795 - 5811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gregori, C. Fuchs, M. E. Figueiredo-Pereira, W. E. Van Nostrand, and D. Goldgaber Amyloid beta-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro J. Biol. Chem., August 25, 1995; 270(34): 19702 - 19708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kosik Alzheimer's disease: a cell biological perspective Science, May 8, 1992; 256(5058): 780 - 783. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
