help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andrade, Z. A.
Right arrow Articles by Grimaud, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrade, Z. A.
Right arrow Articles by Grimaud, J. A.

American Journal of Pathology, Vol 132, 389-399, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

Morphology of chronic collagen resorption. A study on the late stages of schistosomal granuloma involution

ZA Andrade and JA Grimaud
Centro de Pesquisas Goncalo Moniz, Salvador-Bahia, Brazil.

Hepatic periovular schistosomal granulomas produced in mice with 50 cercariae per 10 weeks of infection were seen to involute following curative treatment of schistosomiasis. Residual scars remained, however, and the collagen tissue in them presented morphologic evidence of a slow, progressive degradation that lead to the almost complete disappearance of the lesions 4.5 months after chemotherapy. Ultrastructural changes indicative of collagen degradation were represented by focal lytic dissolution of collagen fibrils and/or by the transformation of such fibrils into a granular electron dense material, a picture different from that seen in more acute models of collagen resorption. In older, involuting granulomas, both type I and III collagens were found up to the end of the resorption process. The immunofluorescence staining for procollagen III and fibronectin correlated with collagen synthesis and the amount of both decreased as the granulomas involuted. Antibodies to CB-peptide (a2 CB3,5 from type I collagen) appeared as a good marker of acute collagen degradation only. Laminin and collagen type IV were absent from the granulomas. Periportal fibrosis produced in mice with 30 cercariae per 20 weeks of infection also presented progressive degradation of collagen 2 and 3 months following curative treatment of schistosomiasis. Present findings suggest that there is not an irreversible fibrotic stage in murine schistosomiasis, that chronic collagen resorption presents peculiar ultrastructural features, that the genetic collagen types are not differentially removed, and that periportal fibrosis in schistosomiasis undergo degradation in a way after specific treatment similar to periovular granulomas.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the American Society for Investigative Pathology.