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American Journal of Pathology, Vol 132, 417-426, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

Megakaryocyte and platelet ultrastructure in the Wistar Furth rat

RM Leven and F Tablin
Biomedical Division, Lawrence Berkeley Laboratory, University of California, Davis 95616.

Wistar Furth (WF) rats were studied and compared with Sprague-Dawley (SD) rats to determine if ultrastructural abnormalities in platelets or megakaryocytes could explain their macrothrombocytopenia. WF rats had one third of the platelet count of healthy rats and two times the platelet volume. Megakaryocyte number was decreased and the size of mature stage three megakaryocytes also was decreased. WF platelets had large membranous inclusions, and otherwise showed normal ultrastructural morphology. The WF megakaryocytes showed abnormal aggregates of the demarcation membrane system. Ruthenium red staining was more intense on WF megakaryocytes and platelets, indicating a possible increase in surface mucopolysaccharides. It is possible that abnormal megakaryocyte membrane structure may lead to WF macrothrombocytopenia.


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Copyright © 1988 by the American Society for Investigative Pathology.