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American Journal of Pathology, Vol 133, 15-21, Copyright © 1988 by American Society for Investigative Pathology


REGULAR ARTICLES

Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin

F Facchetti, C de Wolf-Peeters, DY Mason, K Pulford, JJ van den Oord and VJ Desmet
Department of Pathology, Catholic University of Leuven, Belgium.

To elucidate the lineage of plasmacytoid T cells, their immunophenotype was studied in reactive lymph nodes with a broad panel of monoclonal antibodies. Plasmacytoid T cells expressed several myelomonocytic markers, and almost all markers highly selective for macrophages. They lacked granulocyte-associated and B or T lymphocyte-associated antigens. These results provide strong evidence that plasmacytoid T cells are of monocyte lineage.


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Copyright © 1988 by the American Society for Investigative Pathology.