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American Journal of Pathology, Vol 133, 347-354, Copyright © 1988 by American Society for Investigative Pathology

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Chemotactic peptide-induced arachidonic acid mobilization in human polymorphonuclear leukocytes

GM Galbraith
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425-2230.

Human polymorphonuclear leukocytes prelabeled with tritiated arachidonic acid liberated radiolabeled products when exposed to the chemotactic peptide fMet-Leu-Phe. The effect was enhanced in the presence of phorbol-12-myristate 13-acetate or 1-oleoyl-2-acetyl glycerol; these agents activate phospholipid- and Ca2+-dependent protein kinase C. In contrast, arachidonic acid mobilization was suppressed by two compounds known to inhibit protein kinase C activity: polymyxin B and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine. These results suggest that protein kinase C was involved in arachidonic acid mobilization in leukocytes stimulated with chemotactic peptide.

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