| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 133, 419-423, Copyright © 1988 by American Society for Investigative Pathology
REGULAR ARTICLES |
A Srivastava, P Laidler, RP Davies, K Horgan and LE Hughes
Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom.
The vascularity of 20 primary skin melanomas was assessed histologically. These cases were selected from patients with intermediate thickness melanomas (0.76-4.0 mm thick) treated surgically to provide two groups of ten patients. One group had no evidence of recurrence with a minimum follow-up of 9 years. The second group of ten patients developed locoregional or systemic metastasis under follow-up, and seven of these patients died of disseminated melanoma. Age, sex, Breslow's tumor thickness, and Clark's level of invasion were similar in the two groups. Vascular quantitation was carried out by image analysis after vascular definition by Ulex europaeus-I agglutinin staining. The percentage vascular area at the tumor base in the recurrence group was more than twice that in the recurrence-free group. This study suggests that increased vascularity at the tumor base may have prognostic significance in intermediate thickness melanomas.
This article has been cited by other articles:
 |
|
 |
|
  A. A. Garcia Small Molecules: Big Changes in the Cancer Treatment Paradigm Journal of Pharmacy Practice, February 1, 2008; 21(1): 17 - 35. [Abstract] [PDF]
|
|
|
|
 |
|
 D Sahni, A Robson, G Orchard, R Szydlo, A V Evans, and R Russell-Jones The use of LYVE-1 antibody for detecting lymphatic involvement in patients with malignant melanoma of known sentinel node status J. Clin. Pathol., July 1, 2005; 58(7): 715 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Santamaria, M. Velasco, X. Farre, J. A. Vanrell, A. Cardesa, and P. L. Fernandez Power Doppler Sonography of Invasive Breast Carcinoma: Does Tumor Vascularization Contribute to Prediction of Axillary Status? Radiology, February 1, 2005; 234(2): 374 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Uehara, M. Miyamoto, K. Kato, Y. Ebihara, H. Kaneko, H. Hashimoto, Y. Murakami, R. Hase, R. Takahashi, S. Mega, et al. Expression of Pigment Epithelium-Derived Factor Decreases Liver Metastasis and Correlates with Favorable Prognosis for Patients with Ductal Pancreatic Adenocarcinoma Cancer Res., May 15, 2004; 64(10): 3533 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Buck and S. N. Reske Cellular Origin and Molecular Mechanisms of 18F-FDG Uptake: Is There a Contribution of the Endothelium? J. Nucl. Med., March 1, 2004; 45(3): 461 - 463. [Full Text]
|
|
|
|
 |
|
 S. E. DUFF, C. LI, J. M. GARLAND, and S. KUMAR CD105 is important for angiogenesis: evidence and potential applications FASEB J, June 1, 2003; 17(9): 984 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Dadras, T. Paul, J. Bertoncini, L. F. Brown, A. Muzikansky, D. G. Jackson, U. Ellwanger, C. Garbe, M. C. Mihm, and M. Detmar Tumor Lymphangiogenesis: A Novel Prognostic Indicator for Cutaneous Melanoma Metastasis and Survival Am. J. Pathol., June 1, 2003; 162(6): 1951 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujimoto, T. Abe, N. L. Muller, H. Terasaki, S. Kato, J. Sadohara, R. Kono, O. Edamitsu, T. Ishitake, A. Hayashi, et al. Small Peripheral Pulmonary Carcinomas Evaluated with Dynamic MR Imaging: Correlation with Tumor Vascularity and Prognosis Radiology, June 1, 2003; 227(3): 786 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Robinson and M. Dahiya Basal Cell Carcinoma With Pulmonary and Lymph Node Metastasis Causing Death Arch Dermatol, May 1, 2003; 139(5): 643 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kim, W. Luo, D.-T. Chen, K. Earley, J. Tunstead, L.-Y. Yu-Lee, and S.-H. Lin Antitumor Activity of the 16-kDa Prolactin Fragment in Prostate Cancer Cancer Res., January 15, 2003; 63(2): 386 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E S Bamberger and C W Perrett Angiogenesis in epithelian ovarian cancer Mol. Pathol., December 1, 2002; 55(6): 348 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hlatky, P. Hahnfeldt, and J. Folkman Clinical Application of Antiangiogenic Therapy: Microvessel Density, What It Does and Doesn't Tell Us J Natl Cancer Inst, June 19, 2002; 94(12): 883 - 893. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Lassau, S. Koscielny, M.-F. Avril, A. Margulis, P. Duvillard, T. de Baere, A. Roche, and J. Leclere Prognostic Value of Angiogenesis Evaluated with High-Frequency and Color Doppler Sonography for Preoperative Assessment of Melanomas Am. J. Roentgenol., June 1, 2002; 178(6): 1547 - 1551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Clarijs, I. Otte-Holler, D. J. Ruiter, and R. M. W. de Waal Presence of a Fluid-Conducting Meshwork in Xenografted Cutaneous and Primary Human Uveal Melanoma Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 912 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kashani-Sabet, R. W. Sagebiel, C. M.M. Ferreira, M. Nosrati, and J. R. Miller III Tumor Vascularity in the Prognostic Assessment of Primary Cutaneous Melanoma J. Clin. Oncol., April 1, 2002; 20(7): 1826 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Yu, J. W. Rak, G. Klement, and R. S. Kerbel Vascular Endothelial Growth Factor Isoform Expression as a Determinant of Blood Vessel Patterning in Human Melanoma Xenografts Cancer Res., March 1, 2002; 62(6): 1838 - 1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yuan, C.-J. Yu, K.-T. Luh, S.-H. Kuo, Y.-C. Lee, and P.-C. Yang Aberrant p53 Expression Correlates With Expression of Vascular Endothelial Growth Factor mRNA and Interleukin-8 mRNA and Neoangiogenesis in Non-Small-Cell Lung Cancer J. Clin. Oncol., February 15, 2002; 20(4): 900 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Satyamoorthy, G. Li, B. Vaidya, J. Kalabis, and M. Herlyn Insulin-like Growth Factor-I-induced Migration of Melanoma Cells Is Mediated by Interleukin-8 Induction Cell Growth Differ., February 1, 2002; 13(2): 87 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cianchi, A. Palomba, L. Messerini, V. Boddi, G. Asirelli, G. Perigli, P. Bechi, A. Taddei, F. Pucciani, and C. Cortesini Tumor Angiogenesis in Lymph Node-Negative Rectal Cancer: Correlation With Clinicopathological Parameters and Prognosis Ann. Surg. Oncol., January 1, 2002; 9(1): 20 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Clarijs, L. Schalkwijk, D. J. Ruiter, and R. M. W. de Waal Lack of Lymphangiogenesis Despite Coexpression of VEGF-C and Its Receptor Flt-4 in Uveal Melanoma Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1422 - 1428. [Abstract] [Full Text]
|
|
|
|
|
|
D. Huang, J. L. Rutkowski, G. M. Brodeur, P. M. Chou, J. L. Kwiatkowski, A. Babbo, and S. L. Cohn Schwann Cell-conditioned Medium Inhibits Angiogenesis Cancer Res., November 1, 2000; 60(21): 5966 - 5971. [Abstract] [Full Text]
|
|
|
|
|
|
E. K. Rofstad and E. F. Halsør Vascular Endothelial Growth Factor, Interleukin 8, Platelet-derived Endothelial Cell Growth Factor, and Basic Fibroblast Growth Factor Promote Angiogenesis and Metastasis in Human Melanoma Xenografts Cancer Res., September 1, 2000; 60(17): 4932 - 4938. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Baidas, E. P. Winer, G. F. Fleming, L. Harris, J. M. Pluda, J. G. Crawford, H. Yamauchi, C. Isaacs, J. Hanfelt, M. Tefft, et al. Phase II Evaluation of Thalidomide in Patients With Metastatic Breast Cancer J. Clin. Oncol., July 14, 2000; 18(14): 2710 - 2717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Restucci, G. De Vico, and P. Maiolino Evaluation of Angiogenesis in Canine Mammary Tumors by Quantitative Platelet Endothelial Cell Adhesion Molecule Immunohistochemistry Vet. Pathol., July 1, 2000; 37(4): 297 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tae, A. K. El-Naggar, E. Yoo, L. Feng, J. J. Lee, W. K. Hong, W. N. Hittelman, and D. M. Shin Expression of Vascular Endothelial Growth Factor and Microvessel Density in Head and Neck Tumorigenesis Clin. Cancer Res., July 1, 2000; 6(7): 2821 - 2828. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. M. Ellis, Y. Takahashi, W. Liu, and R. M. Shaheen Vascular Endothelial Growth Factor in Human Colon Cancer: Biology and Therapeutic Implications Oncologist, April 1, 2000; 5(90001): 11 - 15. [Abstract] [Full Text]
|
|
|
|
|
|
A. Canete, S. Navarro, J. Bermudez, A. Pellin, V. Castel, and A. Llombart-Bosch Angiogenesis in Neuroblastoma: Relationship to Survival and Other Prognostic Factors in a Cohort of Neuroblastoma Patients J. Clin. Oncol., January 5, 2000; 18(1): 27 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Placido, C. Carlomagno, F. Ciardiello, M. D. Laurentiis, S. Pepe, A. Ruggiero, G. Tortora, L. Panico, A. D'Antonio, G. Pettinato, et al. Measurement of Neovascularization Is an Independent Prognosticator of Survival in Node-negative Breast Cancer Patients with Long-Term Follow-Up Clin. Cancer Res., October 1, 1999; 5(10): 2854 - 2859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kunz, A. Hartmann, E. Flory, A. Toksoy, D. Koczan, H.-J. Thiesen, N. Mukaida, M. Neumann, U. R. Rapp, E.-B. Brocker, et al. Anoxia-Induced Up-Regulation of Interleukin-8 in Human Malignant Melanoma : A Potential Mechanism for High Tumor Aggressiveness Am. J. Pathol., September 1, 1999; 155(3): 753 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-i. Yamashita, M. Ogawa, M. Abe, and M. Nishida Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase Concentrations Differ in Small Cell and Non-small Cell Lung Cancer Chest, July 1, 1999; 116(1): 206 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hartmann, M. Kunz, S. Kostlin, R. Gillitzer, A. Toksoy, E.-B. Brocker, and C. E. Klein Hypoxia-induced Up-Regulation of Angiogenin in Human Malignant Melanoma Cancer Res., April 1, 1999; 59(7): 1578 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kumar, A. Ghellal, C. Li, G. Byrne, N. Haboubi, J. M. Wang, and N. Bundred Breast Carcinoma: Vascular Density Determined Using CD105 Antibody Correlates with Tumor Prognosis Cancer Res., February 1, 1999; 59(4): 856 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. G. Duarte, B. L. Bufkin, M. F. Pennington, A. A. Gal, C. Cohen, A. S. Kosinski, K. A. Mansour, and J. I. Miller Angiogenesis As A Predictor Of Survival After Surgical Resection For Stage I Non-Small-Cell Lung Cancer J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 652 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Dover and A. W. Valley Review : Angiogenesis: A new target for antineoplastic therapy Journal of Oncology Pharmacy Practice, January 1, 1996; 2(1): 43 - 60. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
