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American Journal of Pathology, Vol 133, 440-445, Copyright © 1988 by American Society for Investigative Pathology
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E Bonilla, B Schmidt, CE Samitt, AF Miranda, AP Hays, AB de Oliveira, HW Chang, S Servidei, E Ricci and DS Younger
Department of Neurology, College of Physicians & Surgeons, Columbia University, Columbia Presbyterian Medical Center, New York, New York.
Dystrophin is the gene product that is affected in Duchenne muscular dystrophy (DMD). Antibodies against dystrophin were used to study the protein in muscle fibers of carriers of the gene. The results showed that DMD carriers have normal and dystrophin-deficient fibers. Dystrophin immunohistochemistry may be helpful for the detection of DMD carriers.
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