This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baumbach, G. L. Articles by Hart, M. N. Search for Related Content PubMed PubMed Citation Articles by Baumbach, G. L. Articles by Hart, M. N.

American Journal of Pathology, Vol 133, 464-471, Copyright © 1988 by American Society for Investigative Pathology

REGULAR ARTICLES

Composition and mechanics of cerebral arterioles in hypertensive rats

GL Baumbach, JG Walmsley and MN Hart
University of Iowa College of Medicine, Department of Pathology, Iowa City 52242.

It was demonstrated recently that, in contrast to large cerebral arteries, distensibility of cerebral arterioles is increased in stroke- prone spontaneously hypertensive rats (SHRSP). The goals of this study were to examine composition of normal cerebral arterioles, and to determine whether chronic hypertension alters relative composition of the arteriolar wall. Pial arterioles in normotensive Wistar Kyoto rats contain large amounts of smooth muscle, small amounts of elastin and basement membrane, and very little collagen. Hypertrophy of pial arterioles in SHRSP is characterized by increases in the elastic components, smooth muscle and elastin. The stiffer components, collagen and basement membrane either did not change or decreased. It is concluded that cerebral arterioles contain proportionately more smooth muscle and less collagen than large arteries, and that hypertrophy of cerebral arterioles in SHRSP is accompanied by a relative increase in the more elastic components of the arteriolar wall, which probably contributes to the increase in arteriolar distensibility.

This article has been cited by other articles:

				H. Guo, J. D. Humphrey, and M. J. Davis Effects of biaxial stretch on arteriolar function in vitro Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2378 - H2386. [Abstract] [Full Text] [PDF]

				J.-M. Chillon and G. L. Baumbach Effects of Indapamide, a Thiazide-Like Diuretic, on Structure of Cerebral Arterioles in Hypertensive Rats Hypertension, May 1, 2004; 43(5): 1092 - 1097. [Abstract] [Full Text] [PDF]

				G. L. Baumbach, C. D. Sigmund, and F. M. Faraci Cerebral Arteriolar Structure in Mice Overexpressing Human Renin and Angiotensinogen Hypertension, January 1, 2003; 41(1): 50 - 55. [Abstract] [Full Text] [PDF]

				G. L. Baumbach, C. D. Sigmund, T. Bottiglieri, and S. R. Lentz Structure of Cerebral Arterioles in Cystathionine {beta}-Synthase-Deficient Mice Circ. Res., November 15, 2002; 91(10): 931 - 937. [Abstract] [Full Text] [PDF]

				O. Regrigny, F. Dupuis, J. Atkinson, P. Liminana, E. Scalbert, P. Delagrange, and J.-M. Chillon Cerebral arteriolar structure and function in pinealectomized rats Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1476 - H1480. [Abstract] [Full Text] [PDF]

				S. Boumaza, S. M. Arribas, M. Osborne-Pellegrin, J. C. McGrath, S. Laurent, P. Lacolley, and P. Challande Fenestrations of the Carotid Internal Elastic Lamina and Structural Adaptation in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, April 1, 2001; 37(4): 1101 - 1107. [Abstract] [Full Text] [PDF]

				O. Regrigny, J. Atkinson, C. Capdeville-Atkinson, P. Liminana, and J.-M. Chillon Effect of Lovastatin on Cerebral Circulation in Spontaneously Hypertensive Rats Hypertension, May 1, 2000; 35(5): 1105 - 1110. [Abstract] [Full Text] [PDF]

				H. D. Intengan, G. Thibault, J.-S. Li, and E. L. Schiffrin Resistance Artery Mechanics, Structure, and Extracellular Components in Spontaneously Hypertensive Rats : Effects of Angiotensin Receptor Antagonism and Converting Enzyme Inhibition Circulation, November 30, 1999; 100(22): 2267 - 2275. [Abstract] [Full Text] [PDF]

				J.-M. Chillon and G. L. Baumbach Effects of an Angiotensin-Converting Enzyme Inhibitor and a ß-Blocker on Cerebral Arterioles in Rats Hypertension, March 1, 1999; 33(3): 856 - 861. [Abstract] [Full Text] [PDF]

				J.-M. Chillon, S. Ghoneim, and G. L. Baumbach Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats Hypertension, November 1, 1997; 30(5): 1097 - 1104. [Abstract] [Full Text]

				S. Nag and D. W. Kilty Cerebrovascular Changes in Chronic Hypertension : Protective Effects of Enalapril in Rats Stroke, May 1, 1997; 28(5): 1028 - 1034. [Abstract] [Full Text]

				J.-M. Chillon, D. D. Heistad, and G. L. Baumbach Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats Hypertension, March 1, 1996; 27(3): 794 - 798. [Abstract] [Full Text]

				G. L. Baumbach Effects of Increased Pulse Pressure on Cerebral Arterioles Hypertension, February 1, 1996; 27(2): 159 - 167. [Abstract] [Full Text]