help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacobsson, B.
Right arrow Articles by Grimelius, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacobsson, B.
Right arrow Articles by Grimelius, L.

American Journal of Pathology, Vol 134, 465-471, Copyright © 1989 by American Society for Investigative Pathology

REGULAR ARTICLES

Transthyretin in endocrine pancreatic tumors

B Jacobsson, A Carlstrom, VP Collins and L Grimelius
Department of Pathology, Danderyd Hospital, Sweden.

The occurrence of transthyretin (TTR) in 25 endocrine pancreatic tumors was investigated by immunohistochemical methods using both polyclonal and monoclonal antibodies. All malignant insulinomas were strongly TTR immunoreactive, more so than their benign counterparts, which in some cases were TTR negative. All glucagonomas and nonfunctioning tumors were TTR immunoreactive, whereas gastrinomas and VIPomas were TTR negative. TTR, chromogranin A, and the argyrophil reaction (Grimelius' silver technique) had similar distributions among the cells in many, but not all, tumors. Coexistence of TTR with glucagon, insulin, or pancreatic polypeptide in tumor cells was demonstrated. TTR was also quantitated in preoperative serum samples by electroimmuno assay in some cases. Although one patient with a glucagonoma had a markedly increased serum TTR level, five other patients with endocrine tumors, including two patients with glucagonoma, had TTR levels in serum that were within or below the reference range.


This article has been cited by other articles:


Home page
 INT J SURG PATHOLHome page
T. J. Giordano, L. J. Medeiros, V. Monterroso, W. M. Linehan, and M. J. Merino
Transthyretin (Prealbumin) Immunoreactivity in Renal Cell Carcinoma and Other Neoplasms
International Journal of Surgical Pathology, July 1, 1996; 4(1): 1 - 7.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American Society for Investigative Pathology.