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American Journal of Pathology, Vol 134, 627-631, Copyright © 1989 by American Society for Investigative Pathology

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Induction of a mixed ductal-squamous-islet cell carcinoma in a rat treated with a tobacco-specific carcinogen

PM Pour and A Rivenson
Eppley Institute, University of Nebraska Medical Center, Omaha 68105- 1065.

Treatment of rats with tobacco-specific nitrosamines resulted in the induction of pancreatic acinar cell and ductal cell neoplasms. One of these tumors had a mixed ductal-squamous-islet cell components, the electron microscopic and immunohistochemical patterns of which are described. This is the first report of such a pancreatic mixed cell neoplasm.

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