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American Journal of Pathology, Vol 134, 741-747, Copyright © 1989 by American Society for Investigative Pathology

REGULAR ARTICLES

S100 protein positive dendritic cells in primary biliary cirrhosis and other chronic inflammatory liver diseases. Relevance to pathogenesis?

AJ Demetris, C Sever, S Kakizoe, S Oguma, TE Starzl and R Jaffe
Department of Pathology, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213.

A study to determine the location of dendritic cells, in chronic inflammatory liver disease was performed. S100 protein positivity and dendritic cytoplasmic morphology were used to identify dendritic cells. S100 protein positive dendritic cells (S100 + DC) were found inside the basement membrane between biliary epithelial cells of septal bile ducts of livers affected by early stage PBC, but were not present at later stages. S100 + DC also were seen in areas of piecemeal necrosis in chronic active hepatitis of various etiologies. In contrast, intra- epithelial S100 + DC were not found with any consistency in sclerosing cholangitis, secondary biliary cirrhosis, extrahepatic biliary atresia, or chronic liver allograft rejection, all of which are characterized by inflammatory bile duct damage. The possible relevance of DC in the pathogenesis of PBC is discussed.


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Copyright © 1989 by the American Society for Investigative Pathology.