| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 134, 1151-1157, Copyright © 1989 by American Society for Investigative Pathology
REGULAR ARTICLES |
MG Hendrix, PH Dormans, P Kitslaar, F Bosman and CA Bruggeman
Department of Medical Microbiology, University of Limburg, Maastricht, The Netherlands.
The presence of cytomegalovirus (CMV) nucleic acids was demonstrated in abdominal aortas and femoral arteries of patients with and without atherosclerosis by dot blot and in situ DNA hybridization using a DNA probe derived from immediate early genomic regions. Viral antigens could not be detected by immunohistochemistry and infectious virus could not be recovered from the arterial wall by virus isolation techniques. The high percentage (55%) of vascular wall specimens containing CMV nucleic acids, in atherosclerotic as well as in control material and the location of CMV-containing cells in arteries without gross changes indicative of atherosclerosis suggest that the human arterial wall may be a site of latency for this virus.
This article has been cited by other articles:
 |
|
 |
|
  S. Gredmark, K. Straat, M. Homman-Loudiyi, K. Kannisto, and C. Soderberg-Naucler Human Cytomegalovirus Downregulates Expression of Receptors for Platelet-Derived Growth Factor by Smooth Muscle Cells J. Virol., May 15, 2007; 81(10): 5112 - 5120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jarvis and J. A. Nelson Human Cytomegalovirus Tropism for Endothelial Cells: Not All Endothelial Cells Are Created Equal J. Virol., March 1, 2007; 81(5): 2095 - 2101. [Full Text] [PDF]
|
|
|
|
|
|
G. L. Bentz, M. Jarquin-Pardo, G. Chan, M. S. Smith, C. Sinzger, and A. D. Yurochko Human Cytomegalovirus (HCMV) Infection of Endothelial Cells Promotes Naive Monocyte Extravasation and Transfer of Productive Virus To Enhance Hematogenous Dissemination of HCMV J. Virol., December 1, 2006; 80(23): 11539 - 11555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jarvis, J. A. Borton, A. M. Keech, J. Wong, W. J. Britt, B. E. Magun, and J. A. Nelson Human Cytomegalovirus Attenuates Interleukin-1{beta} and Tumor Necrosis Factor Alpha Proinflammatory Signaling by Inhibition of NF-{kappa}B Activation. J. Virol., June 1, 2006; 80(11): 5588 - 5598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Froberg, D. Dannen, A. Adams, J. Parker-Thornburg, and P. Kolattukudy Murine Cytomegalovirus Infection Markedly Reduces Serum MCP-1 Levels in MCP-1 Transgenic Mice. Ann. Clin. Lab. Sci., March 1, 2006; 36(2): 179 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Rue, M. A. Jarvis, A. J. Knoche, H. L. Meyers, V. R. DeFilippis, S. G. Hansen, M. Wagner, K. Fruh, D. G. Anders, S. W. Wong, et al. A Cyclooxygenase-2 Homologue Encoded by Rhesus Cytomegalovirus Is a Determinant for Endothelial Cell Tropism J. Virol., November 15, 2004; 78(22): 12529 - 12536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Froberg CMV Escapes! Ann. Clin. Lab. Sci., April 1, 2004; 34(2): 123 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Nerheim, J. L. Meier, M. A. Vasef, W.-G. Li, L. Hu, J. B. Rice, D. Gavrila, W. E. Richenbacher, and N. L. Weintraub Enhanced Cytomegalovirus Infection in Atherosclerotic Human Blood Vessels Am. J. Pathol., February 1, 2004; 164(2): 589 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T-M Lin, W-j Chen, H-Y Chen, P-W Wang, and H-L Eng Increased incidence of cytomegalovirus but not Chlamydia pneumoniae in atherosclerotic lesions of arteries of lower extremities from patients with diabetes mellitus undergoing amputation J. Clin. Pathol., June 1, 2003; 56(6): 429 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Streblow, S. L. Orloff, and J. A. Nelson Do Pathogens Accelerate Atherosclerosis? J. Nutr., October 1, 2001; 131(10): 2798S - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Froberg, N. Seacotte, and E. Dahlberg Cytomegalovirus Seropositivity and Serum Total Cholesterol Levels in Young Patients Ann. Clin. Lab. Sci., April 1, 2001; 31(2): 157 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhou, G. Caligiuri, A. Hamsten, A. K. Lefvert, and G. K. Hansson LDL Immunization Induces T-Cell-Dependent Antibody Formation and Protection Against Atherosclerosis Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 108 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S A Morre, W Stooker, W K Lagrand, A J C van den Brule, and H W M Niessen Microorganisms in the aetiology of atherosclerosis J. Clin. Pathol., September 1, 2000; 53(9): 647 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Hajjar Oxidized Lipoproteins and Infectious Agents : Are They in Collusion to Accelerate Atherogenesis? Arterioscler. Thromb. Vasc. Biol., June 1, 2000; 20(6): 1421 - 1422. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bartels, M. Maass, G. Bein, N. Brill, J. F. M. Bechtel, R. Leyh, and H.-H. Sievers Association of Serology With the Endovascular Presence of Chlamydia pneumoniae and Cytomegalovirus in Coronary Artery and Vein Graft Disease Circulation, January 18, 2000; 101(2): 137 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bodaghi, M. E. P. Slobbe-vanDrunen, A. Topilko, E. Perret, R. C. R. M. Vossen, M. C. E. van Dam-Mieras, D. Zipeto, J.-L. Virelizier, P. LeHoang, C. A. Bruggeman, et al. Entry of Human Cytomegalovirus into Retinal Pigment Epithelial and Endothelial Cells by Endocytosis Invest. Ophthalmol. Vis. Sci., October 1, 1999; 40(11): 2598 - 2607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Zibara, M.-C. Bourdillon, E. Chignier, C. Covacho, and J. L. McGregor Identification and Cloning of a New Gene (2A3-2), Homologous to Human Translational Elongation Factor, Upregulated in a Proliferating Rat Smooth Muscle Cell Line and in Carotid Hyperplasia Arterioscler. Thromb. Vasc. Biol., July 1, 1999; 19(7): 1650 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lucas, E. Dai, L.-Y. Liu, and P. N Nation Atherosclerosis in Marek's disease virus infected hypercholesterolemic roosters is reduced by HMGCoA reductase and ACE inhibitor therapy Cardiovasc Res, April 1, 1998; 38(1): 237 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Libby, D. Egan, and S. Skarlatos Roles of Infectious Agents in Atherosclerosis and Restenosis: An Assessment of the Evidence and Need for Future Research Circulation, December 2, 1997; 96(11): 4095 - 4103. [Full Text]
|
|
|
|
|
|
M. C.J Persoons, M. J.A.P Daemen, E. M van Kleef, G. E.L.M Grauls, E. Wijers, and C. A Bruggeman Neointimal smooth muscle cell phenotype is important in its susceptibility to cytomegalovirus (CMV) infection: a study in rat Cardiovasc Res, November 1, 1997; 36(2): 282 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pauletto, G. Pisoni, R. Boschetto, M. Zoleo, A. C. Pessina, and G. Palu Human Cytomegalovirus and Restenosis of the Internal Carotid Artery Stroke, September 1, 1996; 27(9): 1669 - 1671. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kol, G. Sperti, J. Shani, N. Schulhoff, W. van de Greef, M. P. Landini, M. La Placa, A. Maseri, and F. Crea Cytomegalovirus Replication Is Not a Cause of Instability in Unstable Angina Circulation, April 1, 1995; 91(7): 1910 - 1913. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. K. Froberg, A. Adams, N. Seacotte, J. Parker-Thornburg, and P. Kolattukudy Cytomegalovirus Infection Accelerates Inflammation in Vascular Tissue Overexpressing Monocyte Chemoattractant Protein-1 Circ. Res., December 7, 2001; 89(12): 1224 - 1230. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
