| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 135, 121-133, Copyright © 1989 by American Society for Investigative Pathology
REGULAR ARTICLES |
JM Munro, JS Pober and RS Cotran
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Recombinant human interferon (IFN)-gamma (2 X 10(4) or 2 X 10(5) U), tumor necrosis factor (TNF, 10(4) or 10(5) U), or both were injected intracutaneously into baboons (Papio anubis), and biopsies were examined at various intervals for evidence of altered endothelial cell antigen expression, endothelial morphology, and leukocyte infiltration. IFN-gamma induced increased binding of anti-HLA-DP mAb by 24 hours and a mild-to-moderate accumulation of mononuclear cells. TNF induced increased binding of anti-endothelial leukocyte adhesion molecule (ELAM)-1 mAb by 2 hours that was associated with polymorphonuclear leukocyte accumulation, and increased binding of anti-intercellular adhesion molecule (ICAM)-1 mAb by 9 hours that was associated with the onset of progressive mononuclear leukocyte accumulation. TNF also caused endothelial cell hypertrophy and increased vascular permeability. The combination of IFN-gamma and TNF induced a set of changes that qualitatively resemble those of a delayed hypersensitivity reaction to simian agent 8 envelope antigen. These findings are consistent with the concept that cytokine-activated endothelium plays an important role in the adhesion and subsequent extravasation of leukocytes during immune inflammation.
This article has been cited by other articles:
![]() |
S. Nie, M. Cornberg, and L. K. Selin Resistance to Vaccinia Virus Is Less Dependent on TNF under Conditions of Heterologous Immunity J. Immunol., November 15, 2009; 183(10): 6554 - 6560. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Lionaki, K. Siamopoulos, I. Theodorou, E. Papadimitraki, G. Bertsias, D. Boumpas, and J. Boletis Inhibition of tumour necrosis factor alpha in idiopathic membranous nephropathy: a pilot study Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2144 - 2150. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. P. Carvalho, E. J. Pearce, and P. Scott Functional Dichotomy of Dendritic Cells following Interaction with Leishmania braziliensis: Infected Cells Produce High Levels of TNF-{alpha}, whereas Bystander Dendritic Cells Are Activated to Promote T Cell Responses J. Immunol., November 1, 2008; 181(9): 6473 - 6480. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. D. Bannerman, A. C. W. Kauf, M. J. Paape, H. R. Springer, and J. P. Goff Comparison of Holstein and Jersey Innate Immune Responses to Escherichia coli Intramammary Infection J Dairy Sci, June 1, 2008; 91(6): 2225 - 2235. [Abstract] [Full Text] [PDF] |
||||
![]() |
A Fukushima, T Sumi, K Fukuda, N Kumagai, T Nishida, H Yagita, and H Ueno Interleukin 10 and transforming growth factor {beta} contribute to the development of experimentally induced allergic conjunctivitis in mice during the effector phase Br J Ophthalmol, December 1, 2006; 90(12): 1535 - 1541. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Krueger and K. Callis Potential of Tumor Necrosis Factor Inhibitors in Psoriasis and Psoriatic Arthritis Arch Dermatol, February 1, 2004; 140(2): 218 - 225. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. S. Kluger, S. L. Shiao, A. L. M. Bothwell, and J. S. Pober Cutting Edge: Internalization of Transduced E-Selectin by Cultured Human Endothelial Cells: Comparison of Dermal Microvascular and Umbilical Vein Cells and Identification of a Phosphoserine-Type Di-leucine Motif J. Immunol., March 1, 2002; 168(5): 2091 - 2095. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Shaw, B. N. Perkins, Y.-C. Lim, Y. Liu, A. Nusrat, F. J. Schnell, C. A. Parkos, and F. W. Luscinskas Reduced Expression of Junctional Adhesion Molecule and Platelet/Endothelial Cell Adhesion Molecule-1 (CD31) at Human Vascular Endothelial Junctions by Cytokines Tumor Necrosis Factor-{alpha} Plus Interferon-{gamma} Does Not Reduce Leukocyte Transmigration Under Flow Am. J. Pathol., December 1, 2001; 159(6): 2281 - 2291. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Vuorte, P. J. Lindsberg, M. Kaste, S. Meri, S.-E. Jansson, R. Rothlein, and H. Repo Anti-ICAM-1 Monoclonal Antibody R6.5 (Enlimomab) Promotes Activation of Neutrophils in Whole Blood J. Immunol., February 15, 1999; 162(4): 2353 - 2357. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Xu, B. Poirier, J.-P. Duong Van Huyen, N. Lucchiari, O. Michel, J. Chevalier, and S. Kaveri Modulation of Endothelial Cell Function by Normal Polyspecific Human Intravenous Immunoglobulins : A Possible Mechanism of Action in Vascular Diseases Am. J. Pathol., October 1, 1998; 153(4): 1257 - 1266. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. L. Ramsay, E. O'Brian Smith, S. Hegemier, and S. E. Welty Early Clinical Markers for the Development of Bronchopulmonary Dysplasia: Soluble E-Selectin and ICAM-1 Pediatrics, October 1, 1998; 102(4): 927 - 932. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Melrose, N. Tsurushita, G. Liu, and E. L. Berg IFN-{gamma} Inhibits Activation-Induced Expression of E- and P-Selectin on Endothelial Cells J. Immunol., September 1, 1998; 161(5): 2457 - 2464. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. S. Patel, R. Thiagarajan, J. T. Willerson, and E. T. H. Yeh Inhibition of {alpha}4 Integrin and ICAM-1 Markedly Attenuate Macrophage Homing to Atherosclerotic Plaques in ApoE-Deficient Mice Circulation, January 13, 1998; 97(1): 75 - 81. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. A. Taylor, R. Stauber, S. Rulong, E. Hudson, V. Pei, G. N. Pavlakis, J. H. Resau, and G. F. Vande Woude The Inducibly Expressed GTPase Localizes to the Endoplasmic Reticulum, Independently of GTP Binding J. Biol. Chem., April 18, 1997; 272(16): 10639 - 10645. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Holland and T. Owens Signaling through Intercellular Adhesion Molecule 1(ICAM-1) in a B Cell Lymphoma Line. THE ACTIVATION OF Lyn TYROSINE KINASE AND THE MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY J. Biol. Chem., April 4, 1997; 272(14): 9108 - 9112. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. N. McGill, N. A. Ahmed, F. Hu, R. P. Michel, and N. V. Christou Shedding of L-Selectin as a Mechanism for Reduced Polymorphonuclear Neutrophil Exudation in Patients With the Systemic Inflammatory Response Syndrome Arch Surg, November 1, 1996; 131(11): 1141 - 1147. [Abstract] [PDF] |
||||
![]() |
G. A. Taylor, M. Jeffers, D. A. Largaespada, N. A. Jenkins, N. G. Copeland, and G. F.V. Woude Identification of a Novel GTPase, the Inducibly Expressed GTPase, That Accumulates in Response to Interferon gamma J. Biol. Chem., August 23, 1996; 271(34): 20399 - 20405. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-P. Haring, E. L. Berg, N. Tsurushita, M. Tagaya, G. J. del Zoppo, and M. J Eppihimer E-Selectin Appears in Nonischemic Tissue During Experimental Focal Cerebral Ischemia Stroke, August 1, 1996; 27(8): 1386 - 1392. [Abstract] [Full Text] |
||||
![]() |
E. H. Camejo, B. Rosengren, G. Camejo, P. Sartipy, G. Fager, and G. Bondjers Interferon Gamma Binds to Extracellular Matrix Chondroitin-Sulfate Proteoglycans, Thus Enhancing Its Cellular Response Arterioscler Thromb Vasc Biol, September 1, 1995; 15(9): 1456 - 1465. [Abstract] [Full Text] |
||||
![]() |
Y. Q. Huang, A. E. Friedman-Kien, J. J. Li, and B. J. Nickoloff Cultured Kaposi's Sarcoma Cell Lines Express Factor XIIIa, CD14, and VCAM-1, but Not Factor VIII or ELAM-1 Arch Dermatol, October 1, 1993; 129(10): 1291 - 1296. [Abstract] [PDF] |
||||
![]() |
H Hourihan, T. Allen, and A Ager Lymphocyte migration across high endothelium is associated with increases in alpha 4 beta 1 integrin (VLA-4) affinity J. Cell Sci., January 4, 1993; 104(4): 1049 - 1059. [Abstract] [PDF] |
||||
![]() |
J Cheng, K Turksen, Q C Yu, H Schreiber, M Teng, and E Fuchs Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes & Dev., August 1, 1992; 6(8): 1444 - 1456. [Abstract] [PDF] |
||||
![]() |
B. J. Nickoloff The Cytokine Network in Psoriasis Arch Dermatol, June 1, 1991; 127(6): 871 - 884. [Abstract] [PDF] |
||||
![]() |
M. Cybulsky and M. Gimbrone Jr Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis Science, February 15, 1991; 251(4995): 788 - 791. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |