This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pan, L. Articles by Isaacson, P. G. Search for Related Content PubMed PubMed Citation Articles by Pan, L. Articles by Isaacson, P. G.

American Journal of Pathology, Vol 135, 7-11, Copyright © 1989 by American Society for Investigative Pathology

REGULAR ARTICLES

The bcl-2 gene in primary B cell lymphoma of mucosa-associated lymphoid tissue (MALT)

L Pan, TC Diss, D Cunningham and PG Isaacson
Department of Histopathology, University College and Middlesex School of Medicine, London, England.

The bcl-2 gene rearrangement representing t(14:18) chromosomal translocation is the most frequent karyotypic abnormality in non- Hodgkin's lymphomas of follicle center-cell lineage. By using three bcl- 2 DNA probes, 21 cases of non-Hodgkin's B cell lymphoma arising from gastrointestinal mucosa and eight cases of follicular lymphomas were examined. No rearrangement of the gene could be detected in the group of gastrointestinal lymphomas, although it was identified in 75% of the follicular lymphomas. The findings suggest that these two groups of lymphomas are not a family at genetic level and support the earlier suggestion that B cell lymphomas arising from gastrointestinal mucosa- associated lymphoid tissue are not of follicle center-cell lineage.

This article has been cited by other articles:

				Y.-W. Chen, X.-T. Hu, A. C. Liang, W.-Y. Au, C.-C. So, M. L. Wong, L. Shen, Q. Tao, K.-M. Chu, Y.-L. Kwong, et al. High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma Blood, October 1, 2006; 108(7): 2373 - 2383. [Abstract] [Full Text] [PDF]

				P. Starostik, A. Greiner, A. Schultz, A. Zettl, K. Peters, A. Rosenwald, M. Kolve, and H. K. Muller-Hermelink Genetic aberrations common in gastric high-grade large B-cell lymphoma Blood, February 15, 2000; 95(4): 1180 - 1187. [Abstract] [Full Text] [PDF]

				A. Aiello, M.-Q. Du, T. C. Diss, H.-Z. Peng, F. Pezzella, D. Papini, R. Giardini, S. Pilotti, L.-X. Pan, and P. G. Isaacson Simultaneous Phenotypically Distinct but Clonally Identical Mucosa-Associated Lymphoid Tissue and Follicular Lymphoma in a Patient With Sjogren's Syndrome Blood, October 1, 1999; 94(7): 2247 - 2251. [Abstract] [Full Text] [PDF]

				G. Ott, J. Kalla, A. Steinhoff, A. Rosenwald, T. Katzenberger, U. Roblick, M. M. Ott, and H. K. Muller-Hermelink Trisomy 3 Is Not a Common Feature in Malignant Lymphomas of Mucosa-Associated Lymphoid Tissue Type Am. J. Pathol., September 1, 1998; 153(3): 689 - 694. [Abstract] [Full Text] [PDF]