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American Journal of Pathology, Vol 135, 369-377, Copyright © 1989 by American Society for Investigative Pathology

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Enhanced monocyte progenitor cell proliferation in bone marrow of hyperlipemic swine

LE Averill, RC Meagher and RG Gerrity
Cardiovascular Research Center, Cleveland Research Institute, Ohio 44115.

This study demonstrated for the first time that bone marrow is a target of enhanced in vivo monocytopoiesis in hyperlipemia. A significantly greater number of bone marrow cells (BMC) were recovered per femur in swine fed a hyperlipemic (HL) diet compared with swine fed a normal (N) diet. In addition, a significantly elevated number of monocytic precursors proliferated in HL-swine compared with N-swine BMC cultures grown in standardized media in the absence of an exogenous source of colony stimulating factor (CSF). HL-swine sera stimulated a significant enhancement in the number of proliferating monocytic precursor cells, regardless of whether or not the BMC were from HL- or N-swine. In addition, HL-swine compared with N-swine BMC demonstrated an enhanced intrinsic capacity to form monocytic colonies in culture, irrespective of the source of swine sera used to stimulate growth.

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