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American Journal of Pathology, Vol 135, 529-540, Copyright © 1989 by American Society for Investigative Pathology

REGULAR ARTICLES

Uniform lineage of oligodendrogliomas

SM de la Monte
Charles S. Kubik Laboratory of Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston 02114.

Experimental observations provide evidence that galactocerebroside- containing (GC+) oligodendrocytes and glial fibrillary acidic protein- containing (GFAP+) type 2 astrocytes are derived from A2B5+ progenitor cells. Because the cytomorphologic features of oligodendrogliomas resemble those of non-neoplastic oligodendrocytes, it was speculated that neoplastic oligodendroglial cells also have A2B5+ lineage. This hypothesis was investigated by immunostaining histopathologic sections with monoclonal antibodies to GC, A2B5, and GFAP. In 28 tumors, ubiquitous immunolabeling of neoplastic cells with anti-GC and anti- A2B5 was observed. In addition, GFAP+/A2B5+ astrocytes were present in most mixed glial tumors. The findings suggest that oligodendrogliomas, whether or not they contain foci of astrocytoma, are uniformly derived from A2B5+ progenitor cells.

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