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American Journal of Pathology, Vol 135, 909-919, Copyright © 1989 by American Society for Investigative Pathology

REGULAR ARTICLES

Feline muscular dystrophy with dystrophin deficiency

JL Carpenter, EP Hoffman, FC Romanul, LM Kunkel, RK Rosales, NS Ma, JJ Dasbach, JF Rae, FM Moore and MB McAfee
Department of Pathology, MSPCA/Angell Memorial Animal Hospital, Boston 02130.

This is the first description of a dystrophin-deficient muscular dystrophy in domestic cats. The disorder appears to be of X-linked inheritance because it affected both males of a litter of four kittens. Immunoblotting and immunofluorescent detection of dystrophin showed dystrophin present in control cat muscle but no detectable dystrophin in either affected cat. The feline muscular dystrophy was progressive and histopathologically resembled human Duchenne/Becker muscular dystrophy except for the lack of fat infiltration and the presence of prominent hypertrophy of both muscle fibers and muscles groups in the feline disorder.


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Copyright © 1989 by the American Society for Investigative Pathology.