help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nerenberg, M. I.
Right arrow Articles by Wiley, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nerenberg, M. I.
Right arrow Articles by Wiley, C. A.

American Journal of Pathology, Vol 135, 1025-1033, Copyright © 1989 by American Society for Investigative Pathology

REGULAR ARTICLES

Degeneration of oxidative muscle fibers in HTLV-1 tax transgenic mice

MI Nerenberg and CA Wiley
Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, California.

The HTLV-1 tax gene under control of the HTLV-1 long terminal repeat (LTR) was introduced into transgenic mice. Previously tax protein expression in the muscle and peripheral nerves of three independent mouse lines was reported. Here the localization of this transgenic protein at a cellular and subcellular level is described. Tax protein was expressed in oxidative muscle fibers that developed severe progressive atrophy. It localized to the cytoplasma where it was associated with structures resembling degenerating Z bands. This pattern of muscle fiber involvement is similar to that observed in human retroviral associated myopathy. This transgenic mouse model suggests that preferential expression of the HTLV-1 viral promoter in oxidative muscle fibers may explain the productive infection of these fibers in HTLV-1 myopathy.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
S. Ozden, V. Mouly, M.-C. Prevost, A. Gessain, G. Butler-Browne, and P.-E. Ceccaldi
Muscle Wasting Induced by HTLV-1 Tax-1 Protein: An in Vitro and in Vivo Study
Am. J. Pathol., December 1, 2005; 167(6): 1609 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
I Kitajima, T Shinohara, J Bilakovics, D. Brown, X Xu, and M Nerenberg
Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B
Science, December 11, 1992; 258(5089): 1792 - 1795.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American Society for Investigative Pathology.