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American Journal of Pathology, Vol 135, 977-987, Copyright © 1989 by American Society for Investigative Pathology
REGULAR ARTICLES |
J Locker and M Nalesnik
Department of Pathology, School of Medicine, Presbyterian-University Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
A variety of gene analyses were performed on lymphoid tumors from transplant patients who received cyclosporine A for immunosuppression. Epstein-Barr virus DNA was detected in the tumors, and the structure of circular episomal virus DNA was used as a measure of cell clonality. This analysis was correlated with clonality determined by study of immunoglobulin gene rearrangement. Some of the tumors had DNA rearrangements near the c-myc gene. Analysis suggested the pathogenesis of the tumors and indicated four categories of lymphoproliferation, three neoplastic and one reactive.
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