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American Journal of Pathology, Vol 136, 13-16, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Colonic aberrant crypts in azoxymethane-treated F344 rats have decreased hexosaminidase activity

TP Pretlow, MA O'Riordan, MF Kolman and JA Jurcisek
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.

Aberrant crypts, identified with methylene blue staining of unsectioned colon from carcinogen-treated rats on the basis of their increased size, were examined for the altered expression of hexosaminidase activity. Previously we identified enzyme-altered foci with normal morphology in sections of colon from carcinogen-treated rats. A reduction of histochemically demonstrable hexosaminidase activity was the most consistent marker for these foci. Aberrant crypts, marked with permanent ink and embedded in methacrylate, had a marked decrease of hexosaminidase activity compared to the adjacent, normal crypts. Hexosaminidase may be a marker that will aid in the identification of the molecular basis of colon cancer in a manner similar to that of esterase D and retinoblastoma.


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