help button home button Am J Pathol ASIP MEMBERSHIP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Allsop, D.
Right arrow Articles by Roberts, G. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Allsop, D.
Right arrow Articles by Roberts, G. W.

American Journal of Pathology, Vol 136, 255-260, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease

D Allsop, S Haga, C Bruton, T Ishii and GW Roberts
Department of Molecular Biology, Psychiatric Research Institute of Tokyo, Japan.

Formalin-fixed, paraffin-embedded temporal lobe sections from eight former boxers' brains were examined using an immunohistochemical method with antibodies to amyloid beta protein. In accord with recent observations in Alzheimer's disease, significant numbers of beta- protein immunoreactive neurofibrillary tangles (NFT) were observed in three cases. Most of these immunoreactive NFTs appeared to be tombstone tangles, although not all such tangles were stained. This immunoreaction was completely abolished by preincubation of antibodies with synthetic beta-protein peptides, and the identity of the immunostained NFTs was confirmed by polarization microscopy of sections counterstained with Congo red. However, it is not yet clear if the beta- protein antigens are, in fact, an integral part of paired helical filaments. These observations, together with our recent finding of beta- immunoreactive plaque-like lesions in dementia pugilistica, also emphasize the many similarities in pathology between this condition and Alzheimer's disease.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
G. K. Gouras, J. Tsai, J. Naslund, B. Vincent, M. Edgar, F. Checler, J. P. Greenfield, V. Haroutunian, J. D. Buxbaum, H. Xu, et al.
Intraneuronal A{beta}42 Accumulation in Human Brain
Am. J. Pathol., January 1, 2000; 156(1): 15 - 20.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American Society for Investigative Pathology.