| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 136, 383-390, Copyright © 1990 by American Society for Investigative Pathology
REGULAR ARTICLES |
M Peuchmaur, D Emilie, MC Crevon, P Solal-Celigny, MC Maillot, G Lemaigre and P Galanaud
INSERM U 131, Hopital Antoine Beclere, Clamart, France.
Expression of the IL-2 receptor (Tac antigen/CD25) is documented in malignant lymphomas. Because IL-2 is a major lymphocyte growth factor, an IL-2-dependent growth could be involved in the proliferation of Tac- positive lymphomas. Indeed such a mechanism has been demonstrated experimentally for the growth of T-cell lines. To investigate this point in human lymphomas, we used in situ hybridization to analyze the expression of the IL-2 gene in 20 non-Hodgkin's lymphomas, among which 12 expressed the IL-2 receptor. Nine of these were anaplastic large cell lymphomas expressing the Ki-1-related antigen. We here show that IL-2-producing cells are present in all the lymphomas we analyzed. As a mean, there is no significant difference in the percentage of IL-2- producing cells between Tac-positive and -negative lymphomas. However, the level of IL-2 production is highly heterogeneous in both groups, and the highest density of IL-2-producing cells was observed in 2 Tac- positive lymphomas. Simultaneous detection of cellular antigens and of IL-2 mRNA demonstrates that IL-2 is produced by reactive T cells rather than by tumor cells. These results suggest that if IL-2 is involved in the growth of Tac-positive lymphomas, it acts as a paracrine, rather than an autocrine, factor.
This article has been cited by other articles:
 |
|
 |
|
  K. Robert, F. Vialard, E. Thiery, K. Toyama, P.-M. Sinet, N. Janel, and J. London Expression of the Cystathionine {beta} Synthase (CBS) Gene During Mouse Development and Immunolocalization in Adult Brain J. Histochem. Cytochem., March 1, 2003; 51(3): 363 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Foussat, L. Bouchet-Delbos, D. Berrebi, I. Durand-Gasselin, A. Coulomb-L'Hermine, R. Krzysiek, P. Galanaud, Y. Levy, and D. Emilie Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients Blood, September 15, 2001; 98(6): 1678 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Dieu-Nosjean, C. Massacrier, B. Homey, B. Vanbervliet, J.-J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, et al. Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors J. Exp. Med., September 5, 2000; 192(5): 705 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Machelon, F. Nomé, and D. Emilie Regulated on Activation Normal T Expressed and Secreted Chemokine Is Induced by Tumor Necrosis Factor-{alpha} in Granulosa Cells from Human Preovulatory Follicle J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 417 - 424. [Abstract] [Full Text]
|
|
|
|
|
|
M.-C. Dieu, B. Vanbervliet, A. Vicari, J.-M. Bridon, E. Oldham, S. Ait-Yahia, F. Briere, A. Zlotnik, S. Lebecque, and C. Caux Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites J. Exp. Med., July 20, 1998; 188(2): 373 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G.F. Mueller, M.-C. Rissoan, B. Salinas, S. Ait-Yahia, O. Ravel, J.-M. Bridon, F. Briere, S. Lebecque, and Y.-J. Liu Polymerase Chain Reaction Selects a Novel Disintegrin Proteinase from CD40-Activated Germinal Center Dendritic Cells J. Exp. Med., August 29, 1997; 186(5): 655 - 663. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
