| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 136, 441-450, Copyright © 1990 by American Society for Investigative Pathology
REGULAR ARTICLES |
RP Wuthrich, AM Jevnikar, F Takei, LH Glimcher and VE Kelley
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Intercellular adhesion molecule-1 (ICAM-1) is a cell-surface protein regulating interactions among immune cells. To determine whether altered expression of ICAM-1 occurs in autoimmune lupus nephritis, we studied ICAM-1 expression in kidneys of normal and autoimmune MRL-lpr and (NZBX NZW)F1 (NZB/W) mice. By immunoperoxidase staining, ICAM-1 is constitutively expressed at low levels in proximal tubules (PT), endothelium and interstitial cells in normal C3H/FeJ mice. In nephritic MRL-lpr and NZB/W kidneys, staining for ICAM-1 is increased in the PT, particularly in the brush border, and is prominent in the glomerular mesangium and the endothelium of large vessels. By Western blot analysis, ICAM-1 is not detected in the urine of normal BALB/c and C3H/FeJ or autoimmune MRL-lpr. By Northern blot analysis, nephritic MRL- lpr and NZB/W have a two- to fivefold increase in steady state levels of ICAM-1 transcripts in the kidney as compared with normal or prenephritic mice. This is paralleled by an increase in MHC class II transcripts. In cultured PT cells, ICAM-1 is expressed at basal levels in PT and is increased by the cytokines interferon-gamma, IL-1 alpha, and TNF-alpha. Thus cytokine-mediated upregulation of ICAM-1 in lupus nephritis may promote interaction of immune cells with renal tissue. The predominant apical expression of ICAM-1 opposite to the basolateral Ia expression suggests a novel role for this adhesion molecule in PT.
This article has been cited by other articles:
 |
|
 |
|
  M. U. Norman, W. G. James, and M. J. Hickey Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice J. Leukoc. Biol., July 1, 2008; 84(1): 68 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C.W. Tang, J. C.K. Leung, L. Y.Y. Chan, A. W.L. Tsang, and K. N. Lai Activation of Tubular Epithelial Cells in Diabetic Nephropathy and the Role of the Peroxisome Proliferator-Activated Receptor-{gamma} Agonist J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1633 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bao, I. Osawe, M. Haas, and R. J. Quigg Signaling through Up-Regulated C3a Receptor Is Key to the Development of Experimental Lupus Nephritis J. Immunol., August 1, 2005; 175(3): 1947 - 1955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Y. Chow, D. J. Nikolic-Paterson, E. Ozols, R. C. Atkins, and G. H. Tesch Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1711 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Lewis and D D'Cruz Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus Lupus, March 1, 2005; 14(3_suppl): s17 - s26. [Abstract] [PDF]
|
|
|
|
|
|
L. Ding, M. Zhao, W. Zou, Y. Liu, and H. Wang Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study Lupus, February 1, 2004; 13(2): 113 - 118. [Abstract] [PDF]
|
|
|
|
|
|
P. Wahl, R. Schoop, G. Bilic, J. Neuweiler, M. Le Hir, S. K. Yoshinaga, and R. P. Wuthrich Renal Tubular Epithelial Expression of the Costimulatory Molecule B7RP-1 (Inducible Costimulator Ligand) J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1517 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Hickey, D. C. Bullard, A. Issekutz, and W. G. James Leukocyte-Endothelial Cell Interactions Are Enhanced in Dermal Postcapillary Venules of MRL/faslpr (Lupus-Prone) Mice: Roles of P- and E-Selectin J. Immunol., May 1, 2002; 168(9): 4728 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Riser, J. Varani, P. Cortes, J. Yee, M. Dame, and A. K. Sharba Cyclic Stretching of Mesangial Cells Up-Regulates Intercellular Adhesion Molecule-1 and Leukocyte Adherence : A Possible New Mechanism for Glomerulosclerosis Am. J. Pathol., January 1, 2001; 158(1): 11 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamagishi, T. Yokoo, T. Imasawa, T. Mitarai, T. Kawamura, and Y. Utsunomiya Genetically Modified Bone Marrow-Derived Vehicle Cells Site Specifically Deliver an Anti-Inflammatory Cytokine to Inflamed Interstitium of Obstructive Nephropathy J. Immunol., January 1, 2001; 166(1): 609 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Griffin, K. M. Gilbert, L. W. Lamps, and N. R. Pumford CD4+ T-Cell Activation and Induction of Autoimmune Hepatitis following Trichloroethylene Treatment in MRL+/+ Mice Toxicol. Sci., October 1, 2000; 57(2): 345 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. McHale, O. A. Harari, D. Marshall, and D. O. Haskard TNF-{alpha} and IL-1 Sequentially Induce Endothelial ICAM-1 and VCAM-1 Expression in MRL/lpr Lupus-Prone Mice J. Immunol., October 1, 1999; 163(7): 3993 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kuroiwa, E. G. Lee, C. L. Danning, G. G. Illei, I. B. McInnes, and D. T. Boumpas CD40 Ligand-Activated Human Monocytes Amplify Glomerular Inflammatory Responses Through Soluble and Cell-to-Cell Contact-Dependent Mechanisims J. Immunol., August 15, 1999; 163(4): 2168 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T T. Ng, I E Collins, S B Kanner, M J Humphries, N Amft, R G Wickremasinghe, D D'Cruz, K E Nye, and W J. Morrow Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus Lupus, January 1, 1999; 8(1): 39 - 51. [Abstract] [PDF]
|
|
|
|
|
|
R Herrera-Esparza, O Barbosa-Cisneros, R Villalobos-Hurtado, and E Avalos-Diaz Renal expression of IL-6 and TNF{alpha} genes in lupus nephritis Lupus, March 1, 1998; 7(3): 154 - 158. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Mai, K. F. Hilgers, and H. Geiger Experimental Studies on the Role of Intercellular Adhesion Molecule-1 and Lymphocyte Function–Associated Antigen-1 in Hypertensive Nephrosclerosis Hypertension, December 1, 1996; 28(6): 973 - 979. [Abstract] [Full Text]
|
|
|
|
|
|
N.A. Granholm and T. Cavallo Long-Lasting Effects of Bacterial Lipopolysaccharide Promote Progression of Lupus Nephritis in NZB/W Mice Lupus, December 1, 1994; 3(6): 507 - 514. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
