help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mahadevan, D.
Right arrow Articles by Pasternak, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mahadevan, D.
Right arrow Articles by Pasternak, C.

American Journal of Pathology, Vol 136, 513-520, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Protection against membrane-mediated cytotoxicity by calcium and zinc

D Mahadevan, A Ndirika, J Vincent, L Bashford, T Chambers and C Pasternak
Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, England.

Injection of S. aureus alpha toxin or ultraviolet-inactivated Sendai virus into the mammary gland of lactating mice leads to cytopathic changes in the alveolar cells compatible with a breakdown of their permeability barrier. Simultaneous administration of Ca2+ or Zn2+ prevents such changes, as it does when added to alveolar cells in vitro. It is concluded that increased levels of Zn2+ (and under certain conditions of Ca2+) may exert a protective role that is clinically significant.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
O. Shatursky, R. Bayles, M. Rogers, B. H. Jost, J. G. Songer, and R. K. Tweten
Clostridium perfringens Beta-Toxin Forms Potential-Dependent, Cation-Selective Channels in Lipid Bilayers
Infect. Immun., October 1, 2000; 68(10): 5546 - 5551.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American Society for Investigative Pathology.