This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zink, M. C. Articles by Myers, J. D. Search for Related Content PubMed PubMed Citation Articles by Zink, M. C. Articles by Myers, J. D.

American Journal of Pathology, Vol 136, 843-854, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Pathogenesis of caprine arthritis encephalitis virus. Cellular localization of viral transcripts in tissues of infected goats

MC Zink, JA Yager and JD Myers
Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Pathologic specimens of 18 goats with classical lesions of caprine arthritis-encephalitis (CAE) virus infection were examined morphologically and by in situ hybridization using molecularly cloned CAEV deoxyribonucleic acid (DNA) to determine which tissues and cells of naturally infected goats supported virus replication. Large numbers of cells with viral transcripts were detected in inflamed brain, spinal cord, lung, joints, and mammary gland. These cells were morphologically compatible with macrophages. Fewer cells with viral transcripts were seen in noninflamed tissues. Viral RNA was identified in macrophagelike cells in lung, liver, spleen, and lymph nodes, in cells lining the vessels of brain and synovium, and in epithelial cells of intestinal crypts, renal tubules, and thyroid follicles. These data suggest that the cell tropism of lentiviruses may extend beyond the narrow boundaries of lymphocytes and macrophages.

This article has been cited by other articles:

				T. Igarashi, O. K. Donau, H. Imamichi, Y. Nishimura, T. S. Theodore, R. Iyengar, C. Erb, A. Buckler-White, C. E. Buckler, and M. A. Martin Although Macrophage-Tropic Simian/Human Immunodeficiency Viruses Can Exhibit a Range of Pathogenic Phenotypes, a Majority of Isolates Induce No Clinical Disease in Immunocompetent Macaques J. Virol., October 1, 2007; 81(19): 10669 - 10679. [Abstract] [Full Text] [PDF]

				F. Mordasini, H.-R. Vogt, M.-L. Zahno, A. Maeschli, C. Nenci, R. Zanoni, E. Peterhans, and G. Bertoni Analysis of the antibody response to an immunodominant epitope of the envelope glycoprotein of a lentivirus and its diagnostic potential. J. Clin. Microbiol., March 1, 2006; 44(3): 981 - 991. [Abstract] [Full Text] [PDF]

				L. Bruett and J. E. Clements Functional Murine Leukemia Virus Vectors Pseudotyped with the Visna Virus Envelope Show Expanded Visna Virus Cell Tropism J. Virol., December 1, 2001; 75(23): 11464 - 11473. [Abstract] [Full Text]

				B. A. Morse, L. M. Carruth, and J. E. Clements Targeting of the Visna Virus Tat Protein to AP-1 Sites: Interactions with the bZIP Domains of Fos and Jun In Vitro and In Vivo J. Virol., January 1, 1999; 73(1): 37 - 45. [Abstract] [Full Text] [PDF]

				J. L. Mankowski, D. L. Carter, J. P. Spelman, M. L. Nealen, K. R. Maughan, L. M. Kirstein, P. J. Didier, R. J. Adams, M. Murphey-Corb, and M. C. Zink Pathogenesis of Simian Immunodeficiency Virus Pneumonia : An Immunopathological Response to Virus Am. J. Pathol., October 1, 1998; 153(4): 1123 - 1130. [Abstract] [Full Text] [PDF]