| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 136, 1085-1092, Copyright © 1990 by American Society for Investigative Pathology
REGULAR ARTICLES |
K Kure, WD Lyman, KM Weidenheim and DW Dickson
Department of Pathology (Neuropathology), Albert Einstein College of Medicine of Yeshiva University, Bronx 10461.
Among 102 brains obtained from patients with acquired immune deficiency syndrome (AIDS), 34 cases with subacute AIDS encephalitis were characterized by immunohistochemistry using an antibody that binds to a human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp41. This glycoprotein was detected in mononucleated and/or multinucleated cells in 90% of adult and 50% of pediatric brains with subacute AIDS encephalitis. In addition, many gp41-positive cells with bipolar or multipolar processes were found in 10 cases, and these cells occurred most frequently in the basal ganglia and internal capsule. The phenotype of the gp41-positive cells was determined using an improved double-labeling immunohistochemical technique that employed beta- galactosidase and peroxidase conjugated reagents. Cell-type specific markers for double-labeling included: Ricinus communis agglutinin-1 (RCA-1) for macrophages and microglia; Ulex europaeus agglutinin-1 for endothelium; anti-glial fibrillary acidic protein (GFAP) for astrocytes; anti-amyloid precursor protein for neurons; and anti- leukocyte common antigen for leukocytes. Results of double- immunostaining revealed that gp41-positive cells of all morphologic types, including cells with bipolar or multipolar processes, were double-labeled with RCA-1, but not with markers for astrocytes, neurons, or endothelia. These findings support the contention that HIV- 1 infection of the CNS is predominantly restricted to cells of the macrophage/microglia lineage.
This article has been cited by other articles:
 |
|
 |
|
  H. Wang, J. Sun, and H. Goldstein Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide J. Virol., August 1, 2008; 82(15): 7591 - 7600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. MORDELET, K. KISSA, A. CRESSANT, F. GRAY, S. OZDEN, C. VIDAL, P. CHARNEAU, and S. GRANON Histopathological and cognitive defects induced by Nef in the brain FASEB J, December 1, 2004; 18(15): 1851 - 1861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Argyris, E. Acheampong, G. Nunnari, M. Mukhtar, K. J. Williams, and R. J. Pomerantz Human Immunodeficiency Virus Type 1 Enters Primary Human Brain Microvascular Endothelial Cells by a Mechanism Involving Cell Surface Proteoglycans Independent of Lipid Rafts J. Virol., November 15, 2003; 77(22): 12140 - 12151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Bruce-Keller, A. Chauhan, F. O. Dimayuga, J. Gee, J. N. Keller, and A. Nath Synaptic Transport of Human Immunodeficiency Virus-Tat Protein Causes Neurotoxicity and Gliosis in Rat Brain J. Neurosci., September 10, 2003; 23(23): 8417 - 8422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Canki, J. N. F. Thai, W. Chao, A. Ghorpade, M. J. Potash, and D. J. Volsky Highly Productive Infection with Pseudotyped Human Immunodeficiency Virus Type 1 (HIV-1) Indicates No Intracellular Restrictions to HIV-1 Replication in Primary Human Astrocytes J. Virol., September 1, 2001; 75(17): 7925 - 7933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Williams, S. Corey, S. V. Westmoreland, D. Pauley, H. Knight, C. deBakker, X. Alvarez, and A. A. Lackner Perivascular Macrophages Are the Primary Cell Type Productively Infected by Simian Immunodeficiency Virus in the Brains of Macaques: Implications for the Neuropathogenesis of AIDS J. Exp. Med., April 9, 2001; 193(8): 905 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.D. Connor, G.A. Lammie, J.E. Bell, C.P. Warlow, P. Simmonds, and R.D. Brettle Cerebral Infarction in Adult AIDS Patients : Observations From the Edinburgh HIV Autopsy Cohort Stroke, September 1, 2000; 31(9): 2117 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kuster, M. Opravil, P. Ott, E. Schlaepfer, M. Fischer, H. F. Gunthard, R. Luthy, R. Weber, and R. W. Cone Treatment-Induced Decline of Human Immunodeficiency Virus-1 p24 and HIV-1 RNA in Lymphoid Tissue of Patients with Early Human Immunodeficiency Virus-1 Infection Am. J. Pathol., June 1, 2000; 156(6): 1973 - 1986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Limoges, Y. Persidsky, L. Poluektova, J. Rasmussen, W. Ratanasuwan, M. Zelivyanskaya, D. R. McClernon, E. R. Lanier, and H. E. Gendelman Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice Neurology, January 25, 2000; 54(2): 379 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aquaro, O. Wedgwood, C. Yarnold, D. Cahard, R. Pathinara, C. McGuigan, R. Calio', E. de Clercq, J. Balzarini, and C. F. Perno Activities of Masked 2',3'-Dideoxynucleoside Monophosphate Derivatives against Human Immunodeficiency Virus in Resting Macrophages Antimicrob. Agents Chemother., January 1, 2000; 44(1): 173 - 177. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Hong, L. Schlichter, and R. Bendayan A Na+-Dependent Nucleoside Transporter in Microglia J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 366 - 374. [Abstract] [Full Text]
|
|
|
|
|
|
S. V. Westmoreland, K. C. Williams, M. A. Simon, M. E. Bahn, A. E. Rullkoetter, M. W. Elliott, C. D. deBakker, H. L. Knight, and A. A. Lackner Neuropathogenesis of Simian Immunodeficiency Virus in Neonatal Rhesus Macaques Am. J. Pathol., October 1, 1999; 155(4): 1217 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Adamson, K. L. Kopnisky, T. M. Dawson, and V. L. Dawson Mechanisms and Structural Determinants of HIV-1 Coat Protein, gp41-Induced Neurotoxicity J. Neurosci., January 1, 1999; 19(1): 64 - 71. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
