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American Journal of Pathology, Vol 136, 989-995, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Cytomegalovirus-infected cells express Leu-M1 antigen. A potential source of diagnostic error

JM Rushin, GP Riordan, RB Heaton, RW Sharpe, JD Cotelingam and ES Jaffe
Laboratory Medicine Department, National Naval Medical Center, Bethesda, Maryland 20814.

The authors examined cytomegalovirus (CMV)-infected tissues and Hodgkin's Disease (HD) cases with immunohistochemical assays for Leu-M1 and CMV. The cytologic characteristics were correlated with immunostaining patterns. Cytomegalovirus-infected cells in lymph node, lung, and esophagus sections showed Cowdry type A inclusions, and many had granular cytoplasmic inclusions. All infected cells showed nuclear staining with an anti-CMV antibody. Leu-M1 reacted with CMV-infected cells in cytoplasmic areas, particularly near the nucleus simulating the characteristic staining pattern of Reed-Sternberg (R-S) cells. Cytoplasmic staining intensified as the intranuclear inclusions increased in size. Reed-Sternberg cells showed characteristic Leu-M1 positivity along the cell membrane and golgi zone. At times, Leu-M1 staining of CMV-infected cells was indistinguishable from that of R-S cells. None of the R-S cells reacted with the antibody to CMV. Recognition of the reactivity of Leu-M1 with CMV-infected cells is important in avoiding misdiagnosis of CMV lymphadenitis as HD.




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Copyright © 1990 by the American Society for Investigative Pathology.