This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Herbst, H. Articles by Stein, H. Search for Related Content PubMed PubMed Citation Articles by Herbst, H. Articles by Stein, H.

American Journal of Pathology, Vol 137, 13-18, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

High incidence of Epstein-Barr virus genomes in Hodgkin's disease

H Herbst, G Niedobitek, M Kneba, M Hummel, T Finn, I Anagnostopoulos, M Bergholz, G Krieger and H Stein
Institute of Pathology, Klinikum Steglitz, Free University of Berlin, West Germany.

Tissue specimens from 198 cases of Hodgkin's disease and 151 non- Hodgkin lymphomas, as well as 34 nonmalignant lymph node biopsies were examined for the presence of Epstein-Barr virus (EBV) DNA by polymerase chain reaction. Epstein-Barr virus-specific DNA sequences were detected in DNA extracts from frozen and/or paraffin-embedded tissues of 58% of Hodgkin's disease cases. High and low grade non-Hodgkin lymphomas as well as chronic lymphocytic leukemia biopsies contained EBV DNA in 26%, 14%, and 7% of the cases, respectively. Ten percent of the control lymph nodes with normal histology were EBV positive. In Hodgkin's disease biopsies, subsequent in situ hybridization revealed an exclusive localization of the viral DNA in the tumor cells. These findings suggest an involvement of EBV in the pathogenesis of Hodgkin's disease in a substantial proportion of cases.

This article has been cited by other articles:

				N. Faumont, T. Al Saati, P. Brousset, C. Offer, G. Delsol, and F. Meggetto Demonstration by single-cell PCR that Reed-Sternberg cells and bystander B lymphocytes are infected by different Epstein-Barr virus strains in Hodgkin's disease J. Gen. Virol., May 1, 2001; 82(5): 1169 - 1174. [Abstract] [Full Text]

				S. H. Kim, Y. K. Shin, I.-s. Lee, Y. M. Bae, H. W. Sohn, Y. H. Suh, H. J. Ree, M. Rowe, and S. H. Park Viral latent membrane protein 1 (LMP-1)-induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotype Blood, January 1, 2000; 95(1): 294 - 300. [Abstract] [Full Text] [PDF]

				P. G. Murray, L. J. Billingham, H. T. Hassan, J. R. Flavell, P. N. Nelson, K. Scott, G. Reynolds, C. M. Constandinou, D. J. Kerr, E. C. Devey, et al. Effect of Epstein-Barr Virus Infection on Response to Chemotherapy and Survival in Hodgkin's Disease Blood, July 15, 1999; 94(2): 442 - 447. [Abstract] [Full Text] [PDF]

				G. Niedobitek, E. Kremmer, H. Herbst, L. Whitehead, C.W. Dawson, E. Niedobitek, C. von Ostau, N. Rooney, F.A. Grasser, and L.S. Young Immunohistochemical Detection of the Epstein-Barr Virus-Encoded Latent Membrane Protein 2A in Hodgkin's Disease and Infectious Mononucleosis Blood, August 15, 1997; 90(4): 1664 - 1672. [Abstract] [Full Text] [PDF]

				L. Quintanilla-Martinez, C. Lome-Maldonado, G. Ott, A. Gschwendtner, E. Gredler, E. Reyes, A. Angeles-Angeles, and F. Fend Primary Non-Hodgkin's Lymphoma of the Intestine: High Prevalence of Epstein-Barr Virus in Mexican Lymphomas as Compared With European Cases Blood, January 15, 1997; 89(2): 644 - 651. [Abstract] [Full Text] [PDF]

				P. M. Mauch and J. A. Ferry Case 19-1993- A 39-Year-Old Man with Bilateral Renal Masses a Few Months after Treatment for Hodgkin's Disease, Stage IIA N. Engl. J. Med., May 13, 1993; 328(19): 1406 - 1414. [Full Text]