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American Journal of Pathology, Vol 137, 247-251, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. A case report, with analysis of isolated follicular dendritic cells

HK Parmentier, D van Wichen, DM Sie-Go, J Goudsmit, JC Borleffs and HJ Schuurman
Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.

Follicular dendritic cells (FDC) from axillary lymphoid tissue of a patient with acquired immune deficiency syndrome (AIDS) were analyzed for the presence of gag and env proteins and env mRNA of human immunodeficiency virus type-1 (HIV-1), both in a purified FDC suspension and on frozen sections. Isolated cells with morphologic and immunocytochemical features of FDC expressed HIV-1 core (gag) proteins p15, p17, p24, and envelope (env) protein gp41; in addition HIV-1 env mRNA was detected in some of these cells. This corresponded with intense expression of HIV-1 proteins by FDC in germinal centers in situ, and the presence of HIV-1 mRNA-positive cells in germinal follicles. These findings led us to conclude that FDC are infected and able to produce HIV-1. Such infection may contribute significantly to the destruction of the FDC network during the lymphadenopathy phase after HIV-1 infection.


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N. Nakajima, P. Ionescu, Y. Sato, M. Hashimoto, T. Kuroita, H. Takahashi, H. Yoshikura, and T. Sata
In Situ Hybridization AT-Tailing with Catalyzed Signal Amplification for Sensitive and Specific in Situ Detection of Human Immunodeficiency Virus-1 mRNA in Formalin-Fixed and Paraffin-Embedded Tissues
Am. J. Pathol., February 1, 2003; 162(2): 381 - 389.
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Copyright © 1990 by the American Society for Investigative Pathology.