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American Journal of Pathology, Vol 137, 259-262, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T- antigen hybrid gene

BB Knowles, J McCarrick, N Fox, D Solter and I Damjanov
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.

Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.

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