| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 137, 863-870, Copyright © 1990 by American Society for Investigative Pathology
REGULAR ARTICLES |
MM Zutter, G Mazoujian and SA Santoro
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
The integrin superfamily represents a major class of receptors mediating cell-substrate adhesion. Our recent study of the tissue distribution of the alpha 2 beta 1 integrin, a cell-surface collagen receptor, revealed that high levels of receptor expression were associated with orderly, regulated epithelial cell proliferation. Those observations prompted the present investigation of alpha 2 beta 1 and other integrins in adenocarcinoma of the breast. The alpha 2 beta 1 integrin was highly expressed on the epithelium of the ducts and ductules of normal breast tissue. Normal or nearly normal levels of the receptor were expressed in fibroadenomas. In contrast, markedly decreased or undetectable alpha 2 beta 1 expression was typical of poorly differentiated adenocarcinomas. Well-differentiated lesions exhibited intermediate levels of expression. Similar, but less extensive, decreases in expression were observed for the alpha 5 beta 1 (fibronectin receptor) and alpha v beta 3 (vitronectin receptor). Significant expression of the beta 1 subunit on even poorly differentiated tumors suggests that the expression of other undefined members of the beta 1 family is not reduced to the same low level as alpha 2 beta 1 and alpha 5 beta 1. Expression of the alpha 2 beta 1 integrin was highly correlated with estrogen-receptor expression. Decreased expression of alpha 2 beta 1 and other integrin adhesive protein receptors probably contributes to the altered adhesive properties of tumor cells characteristic of the malignant phenotype.
This article has been cited by other articles:
 |
|
 |
|
  N. Rohwer, M. Welzel, K. Daskalow, D. Pfander, B. Wiedenmann, K. Detjen, and T. Cramer Hypoxia-Inducible Factor 1{alpha} Mediates Anoikis Resistance via Suppression of {alpha}5 Integrin Cancer Res., December 15, 2008; 68(24): 10113 - 10120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J R Puddefoot, U K I Udeozo, S Barker, and G P Vinson The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion. Endocr. Relat. Cancer, September 1, 2006; 13(3): 895 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Pereira, T. Meyer, S. E. Docherty, H. H. Reid, J. Marshall, E. W. Thompson, J. Rossjohn, and J. T. Price Bimolecular Interaction of Insulin-Like Growth Factor (IGF) Binding Protein-2 with {alpha}v{beta}3 Negatively Modulates IGF-I-Mediated Migration and Tumor Growth1 Cancer Res., February 1, 2004; 64(3): 977 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Faraldo, M.-A. Deugnier, S. Tlouzeau, J. P. Thiery, and M. A. Glukhova Perturbation of beta 1-Integrin Function in Involuting Mammary Gland Results in Premature Dedifferentiation of Secretory Epithelial Cells Mol. Biol. Cell, October 1, 2002; 13(10): 3521 - 3531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Lindberg, S. Hedjazifar, and D. Baeckstrom c-erbB2-induced Disruption of Matrix Adhesion and Morphogenesis Reveals a Novel Role for Protein Kinase B as a Negative Regulator of alpha 2beta 1 Integrin Function Mol. Biol. Cell, August 1, 2002; 13(8): 2894 - 2908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, T. G. Diacovo, D. G. Grenache, S. A. Santoro, and M. M. Zutter The {alpha}2 Integrin Subunit-Deficient Mouse : A Multifaceted Phenotype Including Defects of Branching Morphogenesis and Hemostasis Am. J. Pathol., July 1, 2002; 161(1): 337 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Klekotka, S. A. Santoro, A. Ho, S. F. Dowdy, and M. M. Zutter Mammary Epithelial Cell-Cycle Progression via the {alpha}2{beta}1 Integrin : Unique and Synergistic Roles of the {alpha}2 Cytoplasmic Domain Am. J. Pathol., September 1, 2001; 159(3): 983 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Plath, K. Detjen, M. Welzel, Z. von Marschall, D. Murphy, M. Schirner, B. Wiedenmann, and S. Rosewicz A Novel Function for the Tumor Suppressor p16INK4a: Induction of Anoikis via Upregulation of the {alpha}5{beta}1 Fibronectin Receptor J. Cell Biol., September 18, 2000; 150(6): 1467 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Park, T. Inoue, M. Ueda, T. Hirano, T. Higuchi, I. Konishi, H. Fujiwara, and S. Fujii Anti-CD9 monoclonal antibody-stimulated invasion of endometrial cancer cell lines in vitro: possible inhibitory effect of CD9 in endometrial cancer invasion Mol. Hum. Reprod., August 1, 2000; 6(8): 719 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Mizejewski Role of Integrins in Cancer: Survey of Expression Patterns Experimental Biology and Medicine, November 1, 1999; 222(2): 124 - 138. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Zutter, S. A. Santoro, J. E. Wu, T. Wakatsuki, S. K. Dickeson, and E. L. Elson Collagen Receptor Control of Epithelial Morphogenesis and Cell Cycle Progression Am. J. Pathol., September 1, 1999; 155(3): 927 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Keely, E. V. Rusyn, A. D. Cox, and L. V. Parise R-Ras Signals through Specific Integrin {alpha} Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells J. Cell Biol., May 31, 1999; 145(5): 1077 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wang, L. Sun, E. Zborowska, J. K. V. Willson, J. Gong, J. Verraraghavan, and M. G. Brattain Control of Type II Transforming Growth Factor-beta Receptor Expression by Integrin Ligation J. Biol. Chem., April 30, 1999; 274(18): 12840 - 12847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hasegawa, T. Nomura, K. Kishimoto, K. Yanagisawa, and S. Fujita SFA-1/PETA-3 (CD151), a Member of the Transmembrane 4 Superfamily, Associates Preferentially with {alpha}5{beta}1 Integrin and Regulates Adhesion of Human T Cell Leukemia Virus Type 1-Infected T Cells to Fibronectin J. Immunol., September 15, 1998; 161(6): 3087 - 3095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Alford, D Baeckstrom, M Geyp, P Pitha, and J Taylor-Papadimitriou Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels J. Cell Sci., January 2, 1998; 111(4): 521 - 532. [Abstract] [PDF]
|
|
|
|
|
|
W.-c. Ho, C. Heinemann, D. Hangan, S. Uniyal, V. L. Morris, and B. M.C. Chan Modulation of In Vivo Migratory Function of alpha 2beta 1 Integrin in Mouse Liver Mol. Biol. Cell, October 1, 1997; 8(10): 1863 - 1875. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Liapis and K. Hutton Detection of Integrins in Formalin-fixed, Paraffin-embedded Tissues J. Histochem. Cytochem., May 1, 1997; 45(5): 737 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Howlett, N Bailey, C Damsky, O. Petersen, and M. Bissell Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma J. Cell Sci., January 5, 1995; 108(5): 1945 - 1957. [Abstract] [PDF]
|
|
|
|
|
|
P. Keely, A. Fong, M. Zutter, and S. Santoro Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells J. Cell Sci., January 2, 1995; 108(2): 595 - 607. [Abstract] [PDF]
|
|
|
|
|
|
M Yamagata and K Kimata Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican J. Cell Sci., January 9, 1994; 107(9): 2581 - 2590. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
